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Available online /content/13/4/R139 Vol 13 No 4 Open Access Research Effects of inducible nitric oxide synthase inhibition or norepinephrine on the neurovascular coupling in an endotoxic rat shock model 1 1 1 2 Bernhard Rosengarten , Stephanie Wolff , Sabine Klatt and Ralf T Schermuly 1Department of Neurology, Justus Liebig University Giessen, Am Steg 14, 35392 Giessen, Germany 2Department of Internal Medicine II, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany Corresponding author: Bernhard Rosengarten, bernhard.rosengarten@neuro.med.uni-giessen.de Received: 26 Jun 2009 Revisions requested: 22 Jul 2009 Revisions received: 23 Jul 2009 Accepted: 26 Aug 2009 Published: 26 Aug 2009 Critical Care 2009, 13:R139 (doi:10.1186/cc8020) This article is online at: /content/13/4/R139 © 2009 Rosengarten et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The inducible nitric oxide synthase (iNOS) plays a administration. Cytokine levels (tumor necrosis factor-alpha crucial role in early sepsis-related microcirculatory dysfunction. (TNFα), interleukin-6 (IL6), interferon-gamma (IFNγ)) and cell Compared to a catecholamine therapy we tested effects of a destruction markers (neuron-specific enolase (NSE), S-100 specific iNOS-inhibitor (1400W) on the