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Amyloid cascade hypothesis is it true for sporadic…
PERIODICUM BIOLOGORUM UDC 57:61
VOL. 110, No 1, 17–25, 2008 CODEN PDBIAD
ISSN 0031-5362
Mini review
Amyloid cascade hypothesis: is it true for sporadic
Alzheimer’s disease
Abstract
MELITA [ALKOVI]-PETRI[I]
Alzheimer’s disease (AD) is a neurodegenerative disorder in which reli -
Laboratory of Molecular Neuropharmacology able early clinical diagnosis is impossible. Early-onset familial AD form,
Department of Pharmacology caused by mutations of genes involved in Ab pathology, and prevailing
Medical School Croation Institute
for Brain Research, University of Zagreb late-onset sporadic AD (sAD) having age, diabetes type 2 and apolipopro-
[alata 11, 10000 Zagreb, Croatia tein E4 as risk factors, demonstrate convergent clinical (memory loss) and
E-mail: melitas@mef.hr neuropathological (amyloid b /Ab/ and tau protein) changes. Leading
amyloid cascade hypothesis assumes that Ab pathology is the primary cause
Abbreviations: of both AD forms, whereas other neuropathological changes are just down-
stream consequences. Transgenic mice AD models that are most widely used
AD – Alzheimer’s disease; for AD pathophysiology research are designed to expr
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