Developmental regulation of the L-type calcium channel αsub class=a-plus-plus1Csub subunit expression in heart.pdfVIP

Hjellestad et al. Cardiovascular Diabetology 2013, 12:79 CARDIO /content/12/1/79 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients 1* 1 2 1 3,4 Iren D Hjellestad , Marianne C Astor , Roy M Nilsen , Eirik Søfteland and Torbjørn Jonung Abstract Background: The diagnosis of diabetes mellitus (DM) is based on either fasting plasma glucose levels or an oral glucose tolerance test (OGTT). Recently, an HbA1c value of ≥ 48 mmol/mol (6.5%) has been included as an additional test to diagnose DM. The purpose of this study was to validate HbA1c versus OGTT as a method to diagnose DM in vascular surgery patients. Methods: The study population consisted of 345 patients admitted consecutively due to peripheral arterial disease. Sixty-seven patients were previously diagnosed with DM. Glucose levels of OGTT and HbA1c values were analyzed in 275 patients. The OGTT results were categorized into three groups according to the World Health Organization 1999 criteria: 1) DM defined as fasting plasma glucose (FPG) ≥ 7.0 mmol/L and/or two-hour value (2-h-value) ≥ 11.1 mmol/L; 2) intermediate hyperglycaemia, which consists of IGT (FPG 7.0 mmol/L and a 2-h-value between 7.8 mmol/L and 11.1 mmol/L), and IFG (fasting glucose value between 6.1 mmol/L and 7.0 mmol/L with a normal 2-h-value); and 3) normal glucose metabolism defined as FPG 6.1 mmol/L and a 2-