Penile ulcer as a specific clinical manifestation of Waldenstrom’s macroglobulinemia.pdfVIP

CAse report 236 s Penile ulcer as a specific clinical manifestation of Waldenstrom’s macroglobulinemia* Cláudia Cardoso de Macedo Oliveira1 José Antônio Nascimento Bressa1 Fernanda Mendes2 Eduardo Vinicius Mendes Roncada1 Rodrigo Monteiro3,4 Marilda Aparecida Milanez Morgado Abreu1 DOI: /10.1590/abd1806-4841 Abstract: Waldenstrom’s macroglobulinemia is considered a lymphoma by the World Health Organization. Cu- taneous lesions, particularly of a specific type, are rare occurring in 5% of patients. What draws attention in this case is the unusual cutaneous clinical manifestation and its location on the genitals, which has not been described in researched literature, therefore imposing differential diagnosis with other etiologies of genital ulcers. Keywords: Hematologic neoplasms; Penile diseases; Skin ulcer; Waldenstrom macroglobulinemia INTRODUCTION Waldenstrom’s macroglobulinemia (MW) is and central nervous system. Cutaneous lesions, par- considered a lymphoma by the World Health Orga- ticularly of a specific type, are rare, occurring in 5% 1 nization. It is a malignant monoclonal gammopathy of patients. Here is reported a case of MW diagnosed characterized by the presence of bone marrow lym- following an unusual cutaneous manifestation. 2 phocytic infiltration and increased blood viscosity due to the high level of immunoglobulin M (Ig M). Clinical CASE REPORT manifestation may be a consequence of blood hyper- Patient, 52 years old, male, single, born in Cari- viscosity, Ig M deposition in tissues, periph