氯噻酮和氢氯噻嗪应用比较的研究进展.pdfVIP

现代药物与临床 Drugs Clinic 第 29 卷 第 2 期 2014 年 2 月 ·211 · 氯噻酮和氢氯噻嗪应用比较的研究进展 1, 2 1 1* 1* 郑海娟 ，王维亭 ，赵专友 ，汤立达 1. 天津药物研究院 天津市新药安全评价研究中心，天津 300193 2. 天津医科大学，天津 300070 摘 要：噻嗪类利尿剂作为抗高血压一线药物，氯噻酮和氢氯噻嗪是这一类药物中较常使用的利尿剂。近年来，氯噻酮、氢 氯噻嗪引起了众多研究者的关注，有证据显示氯噻酮在治疗高血压的疗效及减少心血管事件方面优于氢氯噻嗪，但氯噻酮还 远没有氢氯噻嗪应用广泛。针对氯噻酮得不到广泛应用的原因，从临床应用、药动学、临床药效学等方面比较二者在减少心 血管事件中的效果，并对氯噻酮、氢氯噻嗪各自复方制剂的研究进展进行了综述。 关键词：氯噻酮；氢氯噻嗪；高血压；心血管事件 中图分类号：R983 文献标志码：A 文章编号：1674 - 5515(2014)02 - 0211 - 06 DOI: 10.7501/j.issn.1674-5515.2014.02.025 Research progress on application comparison between chlorthalidone and hydrochlorothiazide 1, 2 1 1 1 ZHENG Hai-juan , WANG Wei-ting , ZHAO Zhuan-you , TANG Li-da 1. Tianjin Center for New Drug Safety Assessment, Tianjin Institute of Pharmceutical Research, Tianjin 300193, China 2. Tianjin Medical University, Tianjin 300070, China Abstract: Thiazide diuretics as first-line antihypertensive drugs, diuretic drugs of chlorthalidone and hydrochlorothiazide in this category are more commonly used. In recent years, chlorthalidone and hydrochlorothiazide attracted the attention of many researchers. Some evidences proved that the efficacy of chlorthalidone in the treatment of hypertension and reducing cardiovascular events was superior to hydrochlorothiazide, but the applications of chlorthalidone was far from hydrochlorothiazide. In this paper, aiming at the reasons of chlorthalidone not commonly used, the efficacy of chlorthalidone and hydrochlorothiazide on reducing of cardiovascular events was compared from clinical application, pharmacodynamics, clinical pharmacokinetics, and the research progress on the compounds of chlorthalidone and hydrochlorothiazide are also reviewed. Key words: chlorthalidone; hydrochlorothiazide; hyp