内分泌信号传导6.pdf

Environmental Signaling (ES-101) Case 6: Shape Matters Session Objectives Students will be able to: Describe the structure of estradiol and the similarities it shares with many other estrogenic compounds Explain how the estrogen receptor binds these compounds Compare the two forms of the estrogen receptor and the compounds they bind best In this class students consider the shapes of several estrogen mimics, and attempt to explain why cells respond to them as estrogens. Read this passage out loud, or ask for a volunteer to do so. Estrogen is a confusing molecule. It makes male birds sing, it prevents heart disease, and it causes girls to enter puberty. But the multiple effects of estrogen are not its only mystery. Many different molecules, synthetic or produced by plants, fungi, or animals, can create an estrogenic response. What is it about these diverse molecules that allows them to mimic estrogen? What do they have in common? Based on these structural similarities and what you learned about the mechanisms of hormone reception, what can you tell about receptor systems from these molecules? Divide the class into 5 groups, giving each two model sets and one of the chemicals above to build, while giving them these instructions In groups you will use kits to construct a physical model of one of these molecules. If you don’t remember your organic chemistry and have trouble turning the drawing into a model, that’s okay, just ask for help. When all the groups have finished making their molecule, we will compare them and try to find what they all have in common, and then try to infer the characteristics of the receptors from their similarities and differences. CAPTION: 17-β Estradiol is the primary female hormone CREDIT: ChemIDPlus, National Library of Medicine CAPTION: Diethylstilbestrol (DES) is a synthetic chemical that is strongly estro