基于网络药理学的苦参碱抗肝癌作用及机制研究_王珂欣.pdf

888 Acta Pharmaceutica Sinica 2017, 52 (6): 888−896 ·研究论文· 1, 2 1* 1 1 1 3* 王珂欣 , 高 丽 , 周玉枝 , 张建琴 , 秦雪梅 , 杜冠华 ( 1. , 2. , 030006; 3. , 100050) : , SMMC-7721 , , − , , ; , ; Western blot , 12 4 mg·mL−1 SMMC-7721 , 0.51 2 mg·mL−1 SMMC-7721 , (HPSE) 3 (CASP3)Myc (MYC) 2 (MMP2) , 1 (CA1) 1A (REG1A) 1 (CES1) 2 (ALDH2) , Western blot MMP2 , CASP3 , : ; ; ; : R966 : A : 0513-4870 (2017) 06-0888-09 Network pharmacology-based study of anti-hepatoma effects and mechanisms of matrine 1, 2 1* 1 1 1 3* WANG Ke-xin , GAO Li , ZHOU Yu-zhi , ZHANG Jian-qin , QIN Xue-mei , DU Guan-hua (1. Modern Research Center for Traditional Chinese Medicine, 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China; 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China) Abstract : Although multiple studies have shown that matrine can inhibit the proliferation of hepatoma cells, its mechanism of action has not been s