关节内透明质酸治疗踝关节骨性关节炎的系统评价和荟萃分析.pdf

Archives of Physical Medicine and Rehabilitation journal homepage: Archives of Physical Medicine and Rehabilitation 2013;94:951-60 REVIEW ARTICLE (META-ANALYSIS) Effectiveness of Intra-Articular Hyaluronic Acid for Ankle Osteoarthritis Treatment: A Systematic Review and Meta-Analysis Ke-Vin Chang, MD,a,b Ming-Yen Hsiao, MD,c Wen-Shiang Chen, MD, PhD,c Tyng-Guey Wang, MD,c Kuo-Liong Chien, MD, PhDb,d From the aDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital, BeiHu Branch and National Taiwan University College of Medicine, Taipei; bGraduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei; cDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei; and dDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Abstract Objectives: To explore the effectiveness and safety of hyaluronic acid (HA) administration for ankle osteoarthritis (OA), and to investigate the effects of variations in HA regimens on treatment responses. Data Sources: Electronic databases, including PubMed and Scopus, were searched from January 1995 to June 2012. Study Selection: We included randomized controlled trials (RCTs) or prospective cohort studies that employed intra-articular HA to treat ankle OA. Four RCTs, 1 comparative study, and 4 single-arm prospective studies were identified, comprising 354 participants. Data Extraction: We determined effect sizes for selected studies by extracting pain scores from ankle OA or visual analog scales before and after HA or reference treatments. Meta-regression was implemented to determine whether outcomes were modified by vari