5-氟尿嘧啶 壳聚糖载药微球的制备及性能研究.pdf

Material Sciences 材料科学, 2017, 7(9), 776-782 Published Online December 2017 in Hans. /journal/ms /10.12677/ms.2017.79101 Preparation and Properties 5-Fluorouracil-Loaded Chitosan Microsphere Yuting Chen, Fengmei Cheng, Leihao Zhang, Yushuang Miao, Haiqin Yuan, Jing Li College of Material and Textile Engineering, Jiaxing University, Jiaxing Zhejiang rd th th Received: Dec. 3 , 2017; accepted: Dec. 19 , 2017; published: Dec. 28 , 2017 Abstract 5-Fluorouracil/chitosan (5-Fu/Cs) microspheres were prepared in emulsion by using glutaralde- hyde as cross-linking agent, span-80 and magnesium stearate mixture as emulsifier, and paraffin oil-vacuum pump oil mixture as oil phase. The morphology, dimension and drug-encapsulation capabilities of 5-Fu/Cs microspheres were explored. The surface of 5-Fu/Cs microspheres is smooth, and the dimension is regular and uniform (~400 nm); strong interaction between the 5-Fu and Cs has been found. The drug encapsulation efficiency was determined (~87.6%). The micro- spheres showed excellent sustained-release effect in buffer solutions with pH = 7.4 and pH = 1.2, while higher release rate was found in lower pH solution. In addition, the release was also affected by the feed ratio of 5-Fu to Cs. With decreasing weight fraction of 5-Fu, increasing releasing rate was found. Keywords 5-Fluorouracil, Chitosan, Microspheres, Sustained-Release 5-氟尿嘧啶/壳聚糖载药微球的制备及性能研究 陈雨婷，程凤梅，张雷浩，缪玉霜，袁海琴，李 晶 嘉兴学院材料与纺织工程学院，浙江 嘉兴 收稿日期：2017年12月3 日；录用日期：2017年12月19 日；发布日期：2017年12月28 日 摘 要 选择高分子材料壳聚糖为药物载体，戊二醛为交联剂，司班-80和硬脂酸镁为复合乳化剂，液体石蜡和真 文章引用: 陈雨婷, 程凤梅, 张雷浩, 缪玉霜, 袁海琴, 李晶. 5-氟尿嘧啶/壳聚糖载药微球的制备及性能研究[J]. 材料 科学, 2017, 7(9): 776-782. DOI: 10.12