冠状动脉粥样硬化性心脏病英文PPT.ppt

Coronary Atherosclerotic Heart Diseases ;;Contents;Self-study ;What Is Atherosclerosis?;;Atherosclerosis ;;What damage does atherosclerosis cause?;Common location Coronary Heart Disease Carotid Artery Disease Peripheral Arterial Disease Chronic Kidney Disease ;How does atherosclerosis start and progress? ;Elevated levels of cholesterol and triglycerides in the blood High blood pressure Cigarette smoking;Biological processes;Biological processes;Biological processes;Atherosclerosis-Hypothesis;High blood pressure,bacterium,virus,toxin,ox-LDL,immune factor,vasoactive substance. Platelets are activated, adhesion and aggregation of platelets. Lipidoses, growth factor, proliferation of smooth mucle cells, collagen, lipolytic enzyme. ;Pathology and pathophysiology;Initiation of Atherosclerosis;Initiation of Atherosclerosis;;;;Thin Cap Vulnerable Plaque Thrombus Unstable “ Active Volcano” ;Unstable and Stable Plaques;*;Atherosclerosis;clinical manifestation;Laboratory Examination;Laboratory Examination;Risk factors ;Risk factors ;7 years incidence of death/non-fatal MI (East West Study);Risk factors ;Drug therapy;Doubts of patients ;Doubts of patients ;Doubts of patients ;Coronary Heart Disease (CHD);Clinical Type;Silent Myocardial Ischemia;Ischemic Cardiomyopathy;Sudden Cardiac Death;Acute Coronary Syndrome;STABLE ANGINA PECTORIS;Definition;Characteristics; hypoxia ;in angiography Significant coronary lesion with diameter stenosis 70% in 75% pts No significant stenosis in about 5-10% pts, Ischemia may be related to coronary spasm or microvascular dysfunction. ;pathophysiology;symptom：chest pain location behind or slightly to the left of the mid sternum no definite borderline radiated to the left shoulder and upper arm Atypical location: lower jaw, the back of neck; character： tightness, squeezing, burning, pressing, choking, bursting,rarely sharp duration： 3－5 mins precipitating factor exertion or emotional agitation pain reli