bal和局部注入依替米星在支气管扩张合并感染的效果研究.docVIP

BAL和局部注入依替米星在支气管扩张合并感染的效果研究 　　【摘要】 目的：?^察联用支气管肺泡灌洗（bronchoalveolar lavage，BAL）和局部注入依替米星治疗支气管扩张合并感染的临床效果。方法：选取支气管扩张合并感染患者86例，按随机数字表法分为观察组和对照组，每组43例。对照组给予排痰、体位引流、吸氧、抗感染、补液、纠正酸碱平衡等常规对症治疗方法；观察组在对照组疗法基础上加用BAL和局部注入依替米星。比较两组患者的疗效、血气分析指标、症状消失时间、住院时间及不良反应方面的差异。结果：经治疗4周后，两组患者血气分析指标均得到明显改善，与治疗前比较，差异均有统计学意义（P 　　【关键词】 依替米星； 支气管扩张合并感染； 支气管肺泡灌洗； 疗效 　　Study on the Effect of Bronchoalveolar Lavage and Local Injection of Etimicin in Bronchiectasis with Infection/TANG Xiu-zhen，LIN Ming-jiang，LIANG Jin-quan，et al.//Medical Innovation of China，2017，14（03）：052-055 　　【Abstract】 Objective：To observe the clinical effect of bronchoalveolar lavage（BAL） and local injection of Etilmicin in the treatment of bronchiectasis complicated with infection.Method：86 patients with bronchial dilation and infection were selected，according to the random number table method，they were randomly divided into observation group and control group，43 cases in each group.The control group was treated with conventional therapy such as discharge of sputum，body position drainage，oxygen inhalation，anti infection，fluid infusion，and correction of acid-base balance.The observation group was given BAL combined with antibiotic intervention on the basis of conventional therapy.The differences of curative effect，blood gas analysis index，symptom disappearance time，hospitalization time and adverse reaction were compared between the two groups.Result：After treatment 4 weeks，patients with the blood gas analysis were obviously improved of two groups，compared with before treatment，the differences were statistically significant（P 　　【Key words】 Etimicin； Bronchiectasis with infection； Bronchoalveolar lavage； Curative effect 　　First-author’s address：Xinhui People’s Hospital，Jiangmen 529100，China 　　doi：10.3969/j.issn.1674-4985.2017.03.015 　　支气管扩张是一种常见慢性呼吸系统疾病，发病率与病死率相当高，病因多为支气管、肺组织感染和支气管阻塞，两者相互影响造成支气管扩张变形，疾病加重会出现或合并感染[1-2]。支气管扩张范围广泛者易损害肺功能，严重者可引起呼吸衰竭甚至死亡，严重影响患者的生活质量和寿命[3]。 　　随着支气管镜的开发和应用，支气管肺泡灌洗（bronchoalveolarlavage，BAL）逐渐兴起并且