ptpn12在乳腺癌中的表达及其影响指标研究.docVIP

PTPN12在乳腺癌中的表达及其影响指标研究 　　[摘要] 目的 探讨PTPN12在乳腺癌中的表达情况及其影响指标。 方法 选取2011年1月～2012年12月于汕头大学医学院第一附属医院诊治的60例乳腺癌患者为观察组，并选取同时期60例乳腺良性疾病患者为对照组，统计及比较两组患者的PTPN12阳性表达率；比较观察组不同PTPN12表达情况患者的生存期；比较观察组中不同分子分型、EGFR及VEGFR-3表达情况乳腺患者的PTPN12阳性表达率。 结果 观察组患者的PTPN12表达总阳性率低于对照组，且观察组中PTPN12阳性者的生存期长于PTPN12阴性者，同时观察组中不同分子分型、EGFR及VEGFR-3表达情况者的PTPN12表达总阳性率比较，差异均无统计学意义（均P 　　[关键词] PTPN12；乳腺癌分子分型；表皮生长因子受体；血管内皮生长因子受体3 　　[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-7210（2017）02（b）-0090-04 　　[Abstract] Objective To investigate the expression situation of PTPN12 in the patients with breast cancer and its influence indexes. Methods Sixty patients with breast cancer in the First Affiliated Hospital of Shantou University Medical College from January 2011 to December 2012 were selected as the observation group， 60 patients with breast benign lesions at the same period were selected as the control group. The positive expression rate of PTPN12 in the two groups was counted and compared； the survival time of patients with different expression situation of PTPN12 in the observation group were compared； the positive expression rate of PTPN12 in the observation group with different molecular typing， EGFR and VEGFR-3 expression situation were compared. Results The total positive expression rate of PTPN12 in the observation group was lower than that of control group， and the survival time of patients with positive expression of PTPN12 in the observation group were longer than those with negative expression of PTPN12， the total positive expression rate of PTPN12 in the observation group with different molecular typing， EGFR and VEGFR-3 expression situation had statistically significant differences （P 　　1.1 一般资料 　　选取2011年1月～2012年12月汕头大学医学院第一附属医院（以下简称“我院”）诊治的60例乳腺癌患者为观察组，选取同时期我院诊治的60例乳腺良性疾病患者为对照组。对照组患者均为女性，年龄33～66岁，平均（44.8±4.8）岁；其中乳腺增生41例，乳腺纤维腺瘤19例。观察组患者也均为女性，年龄31～67岁，平均（44.6±5.0）岁；病灶直径1.1～5.2 cm，平均（2.2±0.5）cm；病灶部位：外上象限45例，其他部位15例；分子分型：Luminal A型18例，Luminal B型17例；HER2（+）型13例，三阴型12例；EGFR表达情况：（-）者22例，（+）者10例，（++）者18例，（+++