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核医学nuclearmedicinePPT
G L U T PLASMA TISSUE FDG Fluorodeoxyglucose Metabolism [18F]Fluorodeoxyglucose (FDG) PET Control Alzheimer’s Disease Center for Functional Imaging; Life Sciences Division; Lawrence Berkeley National Laboratory; Berkeley, CA. Brain Metabolism ([18F]FDG) [11C]Raclopride PET Brain Study Normal Cocaine Abuser Courtesy BNL PET Project nCi/cc 1000 800 600 400 200 0 Therapeutic Nuclear Medicine Fission products useful in nuclear medicine include: 99Mo, 131I, 133Xe, 137Cs and 90Sr Mo-99 I-131 Differentiated Thyroid Carcinoma 5 mCi Na131I Imaging Treatment Planning 48 h p.i. Differentiated Thyroid Carcinoma Therapy 105 mCi Na131I 27 h p.i. Differentiated Thyroid Carcinoma Post Surgical Resection Therapy 57Co Flood Source + 105 mCi Na131I Differentiated Thyroid Carcinoma 201TlCl and 99mTc-Sestamibi Imaging 4 months after Na131I Therapy Canine Osteosarcoma Tumor distal radius Story of QuadraMetTM -- I 153Sm identified as a useful nuclide for radiotherapy by MU researchers Development began in early 1980’s at MU in collaboration with the Dow Chemical Company [phosphonate ligand complexes;153Sm-EDTMP] Successful in treatment of primary osteosarcoma in canine patients, with added bonus of 18% cure rate [MU College of Veterinary Medicine] One of Our First Patients Bone Scans of Canine Patient Before Treatment: 8/15/85 After Treatment: 3/3/86 Results of Clinical Trial of 153Sm-EDTMP in Canine Osteosarcoma Response # of Dogs (%) Survival (months) Disease Free 7 (18%) 11 - 60 Partial Response 25 (62%) 1 - 16 No Response 8 (20%) 0.5 - 1 Story of QuadraMet? -- II Clinical trials began in late 1980’s, with doses supplied by MURR for Phase I studies ~80% efficacy, with ~25% obtaining full pain remission Approved in U.S. for pain palliation of metastatic bone cancer in March, 1997 153Sm-EDTMP [QuadraMet] 99mTc-MDP 153Sm-EDTMP N N PO 3 H 2 PO 3 H 2 PO 3 H 2 PO 3 H 2 153Sm + Experimental Nuclear Medicine Targeting vector (e.g., mAb, peptide hormone, small molecule, etc.) Radio
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