医学统计论文范例---盐酸托烷司琼氯化钠注射液治疗化疗.doc

盐酸托烷司琼氯化钠注射液治疗化疗 所致恶心和呕吐的疗效和安全性的观察 ,### （兖州久益医院，山东 兖州 272100） 摘 要：目的 评价盐酸托烷司琼氯化钠注射液治疗含顺铂或阿霉素方案化疗所致恶心和呕吐的疗效和安全性。方法 对入选的110例患者进行随机交叉对照设计，分AB、BA两组。AB组第一周期用盐酸托烷司琼氯化钠注射液，第二周启用欧必停；BA组相反。化疗方案中顺铂（≥80mg/）分3天用，阿霉素（≥50mg/）在1日内给予，每21-28天重复。结果 AB和BA两组患者呕吐次数差异、恶心程度差异、几个组第一二阶段间差异无统计学意义（P＞0.05）。盐酸托烷司琼和欧必亭对生命体征无影响，按前者为8.3%、后者为11.1% ，不良事件发生率良药间的差异无统计学意义（P＞0.05）。结论 盐酸托烷司琼氯化钠注射液治疗化疗药物所致恶心、呕吐是安全和有效的。 关键词： 盐酸托烷司琼；疗效；安全性；恶心；呕吐 中图分类号： 文献标识码： 文章编号：1672-979X(2006) Hydrochloric acid tropane department fine jade sodium chloride inoculation fluid treatment chemotherapyIs the result of curative effect which disgusting and vomits and secure observation Qi Zhongshun,Liuwenwen (Yanzhoujiuyi Hospital,Shandong Yanzhou 272100) Abstract: Objective The appraisal hydrochloric acid tropane department fine jade sodium chloride inoculation fluid treatment contains the curative effect and the security which is the result of along the platinum or the Arab League mildew element plan chemotherapy disgusting and vomits. Method Carries on the stochastic overlapping comparison design to the selected 110 examples patient, divides AB, the BA two groups. The AB group first cycle with the hydrochloric acid tropane department fine jade sodium chloride inoculation fluid, the second week begins using Ou Biting, the BA group is opposite. In chemotherapy plan, along platinum (≥80mg/m2) divides 3 day to use, Arab League mildew element (≥ 50mg/m2) gives in 1st, every 21-28 day repetition. Result AB, the BA two group of patients vomit the number of times difference, the disgusting degree difference, several groups during 12th stage the difference do not have statistics significance (P 0.05). Hydrochloric acid tropane Si Qiong and Ou Biting does not have the influence to the life symptom, according to former is 8.3%, latter is 11.1%, difference between not the good event formation rate good medicine does not have statistics significance (P 0.05). Conclusion The hydrochloric acid tropane department fine jade sodiu