微生态制剂及研发新思路-在药上的应用.ppt

微生态制剂及研发新思路 -在药上的应用 上海双金生物科技有限公司 傅利剑 益生菌的概念 Probiotics are live micro-organisms which,when administrated in adequate amounts, confer a health benefit on the host. 益生菌是活动微生物，当摄入充足的数量时，对宿主产生一种或多种经过论证的功能性健康益处。 Potential and established effects of probiotic bacteria (adapted from Sanders and Huis in’t Veld, 1999) 益生菌的功效 Continuous 益生菌的功效-消化系统 整肠作用，改善便秘、腹泻等肠道不适症状 抑制肠内有害细菌生长及毒素产生 解决乳糖不耐症 促进营养物质的吸收 Table 4 Targets and postulated mechanisms of probiotic influence on abnormal gastroi- ntestinal conditions. Many studies were designed as pilot studies (small numbers of subjects, not blinded) and results have not been confirmed in large trials Intestinal Conditions Mediated by Probiotic Bacteria Reference Antibiotic-associated diarrhea Orrhage et al., 1994 Toxic amines in blood stream of chronic kidney and liver disease Muting et al., 1968 patients with small bowel bacterial overgrowth Simenhoff et al., 1996 Inflammatory bowel diseases Kruis et al., 1997 Lactose intolerance symptoms Suarez et al., 1995 Rotavirus or other pediatric diarrhea Belloma et al. 1980 Majamaa et al., 1995 Saavedra, et al., 1994 Vanderhoof and Young, 1998 Intestinal permeability to antigens (rats) Isolauri et al., 1993a, b Travellers’ diarrhea