ins、igfbp-7、glo-i在子宫内膜癌患者 血清中的表达及其临床意义word论文.docxVIP

摘要方法收集2013年9月—2014年2月因子宫内膜癌在我院住院手术患者60例，其中绝经31例，高血压8例，糖尿病4例，高血压合并糖尿病2例，均经病理证实且患者术前均未接受放射治疗和化学治疗。同期术后病理证实为子宫内膜不典型增生患者60例，其中绝经15例，高血压10例，糖尿病5例，高血压合并糖尿病1例，子宫内膜多发息肉住院手术患者60例，绝经5例，高血压6例，糖尿病2例，选择同期我院体检中心正常妇女60例，绝经10例，高血压6例，糖尿病5例，高血压合并糖尿病2例。采集取患者（手术病人术前）清晨空腹肘静脉血5ml,离心取血清。ELISA 试剂盒均购自依莱瑞特生物科技有限公司，应用ELISA法检测血清中INS、IGFBP-7、GLO-I的表达水平。结果1.血清INS、IGFBP-7、GLO-1在子宫内膜癌表达水平显著高于子宫内膜不典型增生组，子宫内膜不典型增生组显著高于子宫内膜息肉组和正常子宫内膜组。2.血清INS、IGFBP-7、GLO-1在子宫内膜息肉组和正常子宫内膜组表达差异无统计学意义。3.子宫内膜癌中血清INS与IGFBP-7表达水平成正相关,血清IGFBP-7与GLO-1 表达水平成正相关，INS 与GLO-1 表达水平呈正相关。4.年龄、肥胖指数对子宫内膜癌的发生有影响。年龄越大，肥胖指数越高，患子宫内膜癌的风险越大。结论INS、IFFBP-7、GLO-1升高是子宫内膜癌发生的相关因素。检测血清中IGFBP-7、GLO-1水平，结合患者年龄及肥胖指数可用于评估子宫内膜癌的发生风险,从而有利于早期预防。关键词：子宫内膜癌；INS；IGFBP-7；GLO-IIIINS,IGFBP-7,GLO-1expressioninendometrialcancerpatientsserumanditsclinicalsignificancePostgraduateMeng-Jie Zhang SupervisorAijunLiDepartment ofObstetricsand GynecologyThe FirstAffiliatedHospital of ZhengZhou University Zhengzhou Henan 450052AbstractObjectiveEndometrialcancer（endometrialcarcinoma,EC)isoneofthethreemalignant tumorsoffemalegenitaltract,accountingfor 7%ofthefemalemalignanttumor,with thechangeofthelivingenvironmentandthewayinrecentyears,itsincidenceis increasingtrend,whileitsexactetiologyandpathogenesisisnotveryclear.Suchas diabetes,highbloodpressure,obesityisariskofendometrialcancerriskfactors,is thecommonpathologicalbasisofinsulinresistanceandsecondaryhighbloodinsulinandglucosemetabolismdisorders.Insulin,InsulinandINS)anditshighlyaffinity insulin-likegrowthfactorbindingprotein7(Insulin-likegrowthfactorbinding protein,IGFBP-7)theinteractionofinduced\Insulinresistance\phenomenon,at thesametime,throughtheregulationofcellmetabolism,growthcaninducethe occurrenceof tumor cell development.IIIMethodsCollectedinSeptember2013-February2014for60patientswithendometrial carcinomainourhospitalsurgery,including31cases,menopausehypertension8 cases, 4casesof diabetes, high blood pressure,diabetes mellitus in 2 cases,all has not beenconfirmedbypathologyandpreoperativepatientswithradiationth