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nmda受体亚单位nr1在成人脑组织中的表达研究word论文.docx

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nmda受体亚单位nr1在成人脑组织中的表达研究word论文

DistributionofN-Methyl-D-aspartatereceptorsubunit1intheadultbrainAbstractObjective：To studythe distributionsof N-Methyl-D-aspartatereceptor subunit 1 (NMDAR1)in the adult brain and comparethe distributions in different regions of the adult brain. With thesedata, the roleofNMDAR1 and the mechanisms ofalcohol addiction and drug addiction will be studied better in future.Furthermore, thesedataare also helpful to thelocation in therapies fordrugaddiction bysurgeryand Deep Brain Stimulation.Methods：Five adult brains were collected and madeto tissue chips. Detect thedistributions of NMDAR1 in different regions of the adult brain byimmunohistochemistry,compare the NMDAR1 expression levels in different brain regions between male andfemle.Results：Immunohistochemistryresults showed NMDAR1distributes in all parts ofthe adult brain. NMDAR1 positive cells wereidentified bybrown staining cell membranceand light brown stainingcytoplasm,and sometimes nucleoli can beseen too;theexpression levels of NMDAR1 arevarious in different brain regions(P＜0.05).Theexpression levels areshowed from higher to lower: Hippocampus, Cerebralcortex, Corpus striatum,Thalamus, Brainstem, Cerebellum; the expression levevl of NMDAR1 in dentategyrus is higher than that inHippocampus CA1,CA2,CA3regions (P＜0.05).However,Thereis no significant differencebetween theexpressionlevels of NMDAR1 in Hippocampus CA1,CA2,CA3 regions (P＞0.05).Conclusions：1.NMDAR1distributeswidelyintheadultbrain，thedifferentbrainregionswhich havehigherexpresslevelofNMDAR1tolowerareasfollows:Hippocampus, Cerebralcortex, Corpus striatum,Thalamus, Brainstem, Cerebellum;22. Theexpression level ofNMDAR1 in dentategyrus is the highest in Hippocampus, no significant differencehas been detected in CA1,CA2,CA3 regions.Postgraduate: FengTang (Forensic Medicine)DirectedbyProfessor: PingXiongKey words:The alcohol addiction;NMDAR1;The adult brain;TissueChip;Immunohistochemistry3中英文缩略词对照表英文缩写英文全称中文全称NMDAN-Methyl-D-aspartateN-甲基-D-天门冬氨酸NMDAR1N-Methyl