nt-probnp及tei指数对新生儿缺氧性肺动脉高压右心室功能评价的意义word论文.docxVIP

2 生后第一天各组 Tei 指数及血浆 NT-proBNP 比较观察组 NT-proBNP 及Tei 指数均高于对照组，差异均有统计学意义（P＜0.05）；中度及重度 HPH 组 高于非 HPH 组和轻度 HPH 组，差异均有统计学意义（P＜0.05）；重度 HPH 组高 于中度 HPH 组，差异均有统计学意义（P＜0.05）；非 HPH 组与轻度 HPH 组比较， 差异均无统计学意义（P＞0.05）。3 生后第 7 天 HPH 恢复正常组及未恢复正常组 RVEF、E/A 比值、Tei 指数及 血浆 NT-proBNP 与第一天比较生后第 7 天 HPH 恢复正常组 RVEF、E/A 比值高 于第一天，Tei 指数及血浆 NT-proBNP 低于第一天，差异均有统计学意义（P＜ 0.05）；HPH 未恢复正常组与第一天比较，Tei 指数及血浆 NT-proBNP 降低，差 异有统计学意义（P＜0.05），RVEF、E/A 比值升高，差异无统计学意义（P＞0.05）。 4 生后第一天 NT-proBNP 与 Tei 指数的相关性RV-Tei 与血浆 NT-proBNP呈正相关（r=0.826，P=0.000）。5 生后第一天 RV-Tei 及血浆 NT-proBNP 与 PASP 的相关性 RV-Tei 与 PASP 呈正相关（r=0.555，P=0.000），血浆 NT-proBNP 与 PASP 呈正相关（r=0.504， P=0.000）。结论1、新生儿缺氧性肺动脉高压患儿血浆 NT-proBNP 水平、RV-Tei 升高，提示 新生儿缺氧性肺动脉高压患儿右心功能障碍。2、新生儿缺氧性肺动脉高压患儿血浆 NT-proBNP 水平、RV-Tei 与 PASP 高 低密切相关。3、联合检测血浆 NT-proBNP 及 RV-Tei 可提高新生儿缺氧性肺动脉高压患儿 右心功能障碍诊断率。4、相对于传统超声右心功能测定指标 RVEF、E/A 比值，RV-Tei 评价新生儿 缺氧性肺动脉高压患儿右心功能障碍敏感性更高。关键词 肺动脉高压，缺氧性；血浆 NT-proBNP；Tei 指数；新生儿2The significance of NT-proBNP and Tei index evaluating the right ventricular function in neonates with hypoxic pulmonary hypertensionAbstractObjective To determine the association between NT-proBNP and Tei index in newborns with hypoxic pulmonary,and their values on evaluating the right ventricular function.Methods Between June 2012 and November 2013, we studied 72 newborns with perinatal hypoxia,who were admitted to the neonate intensive care unit(NICU) of Chenzhou NO.1 hospital affiliated to University of South China. All of 72 newbornswere divided into hypoxic pulmonary hypertension(HPH ) group(46 newborns) andnon-HPH group(26 newborns) on the basis of HPH. The group of HPH was grouped into parts ofmild (20 newborns)、moderate (18 newborns) and severe（8 newborns） according to the level of PASP within the first day of life, while in the 7th day ,Thegroup of HPH was divided into two group in the light of whether PASP came to normal. 22 cases of ordinary neonates without perinatal hypoxia history, checked in hospital in the corresponding period, were selected to be control