opg及trail在骨肉瘤中的表达及其意义word论文.docxVIP

结论：1.OPG、TRAIL 可能分别在骨肉瘤细胞存活、凋亡机制中起作用;2.在骨肉瘤中OPG 的高表达可能抑制了TRAIL的表达，同时可能与大量肿瘤骨的形成有关；3.OPG、TRAIL可能与骨肉瘤侵袭转移有关。关键词：OPG；TRAIL；骨肉瘤；骨软骨瘤；免疫组织化学2TheexpressionanditsmeaningofOPGandTRAILinOsteosarcomaAbstractObjective:ThisarticlemainlystudiedtheexpressionofOPGandTRAILinosteosarcoma andosteochondromabyImmunohistochemicalmethods,andpreliminarydiscussionedthe possiblesignificanceandrelevanceofthemintheoccurrenceanddevelopmentof osteosarcoma.Methods:TheexpressionofOPGandTRAILin50casesofosteosarcomaand10casesof osteochondromawasdetectedbyImmunohistochemicalSABCmethod,then,SPSS19.0 wasusedtoanalyzetheresults;andthus,wecanpreliminarilyexploreitssignificanceand analyzethe correlationofthem.Results:1.OPGmainlyexpressedinosteosarcomacellcytoplasm,Therewere36cases werepositivein50patientswithosteosarcoma,thepositiveratewas72.00%;whileonly2 caseswerepositivein10casesofosteochondroma,thepositiveratewas20.00%.Which havesignificantdifferencebetweenthetwogroups(P0.05).TheexpressionofOPGin differentpathologicaltissuetypingwasnosignificantdifference(P0.05),However,the expression ofOPG in thedifferent Enneckingstageswas obvious difference(P0.05).TRAILmainlyexpressedinthemembraneofosteosarcomacell,Therewere16cases werepositivein 50 patients with osteosarcoma, thepositive rate was32.00%; while 7 cases werepositivein10casesofosteochondroma,thepositiveratewas70.00%.Whichhave significantdifferencebetweenthetwogroups(P 0.05).TheexpressionofTRAILwasno significantdifferenceindifferentpathologicaltissuetypingandthedifferentEnnecking installments in osteosarcoma (P0.05).ThepositiverateofOPGinthetransfergroupofosteosarcomawas93.30%,andinthe non-transfergroupwas58.82%.theexpressionofOPG-positiverateinthetwogroupswas3significantlydifferent(P0.05).While,thepositiveimmunostainingrateofTRAILinthe transfergroupofosteosarcomawas17.39%,andintheon-transfergroupwas31.25%.the expression ofTRAIL-positive rate in the twogroupswas dramaticallydifferent (P0.05).4、OPGandTRAILexpressioninosteosarcomawasnegativelyrelatedand