p-asap对sd大鼠的促生长作用及其机理分析word论文.docxVIP

且有显著性差异（P0.05），而 NPY 和 T3 水平差异均不显著（P0.05）。 试验表明，p-ASAP 与 p-ASA 对大鼠血清 IGF-1 水平无显著影响（P0.05）。4、第 18d，各试验组肝脏总砷残留量均极显著高于 A 组（P＜0.01）；p-ASAP 组 和 p-ASA 组，随添加剂量递增而升高；p-ASAP 与 p-ASA 同等剂量组间相比，差异 不显著（P＞0.05）。第 36d，各试验组肝脏总砷残留量均高于 A 组，其中，B、E、F 组极显著升高（P＜0.01）；p-ASAP 与 p-ASA 同等剂量组间相比，p-ASAP 组肝脏总 砷残留量低于对应的 p-ASA 组，但差异不显著（P＞0.05）。第 18d 和 36d，各试验组粪便中的总砷含量均极显著高于 A 组（P＜0.01），且随 添加剂量的递增而升高；p-ASAP 与 p-ASA 同等剂量组间相比，p-ASAP 组粪便中的 总砷含量低于 p-ASA 组，其中，C 组显著低于 F 组（P＜0.05）。总体上看，p-ASAP 组粪便中砷残留量低于 p-ASA 组。结论：饲料中添加 p-ASAP，显著改善大鼠的生长性能，提高粗蛋白、粗脂肪和 粗纤维消化率，降低了肝脏和粪便中总砷的残留量。关键词: 对氨基苯胂酸，纳米，促生长，激素，残留IIAbstractArsanilic acid (p-Arsanilic acid, p-ASA) has been used as feed additives in animal husbandry for many years. The pollution of water and soil caused by arsanilic acid are growing more serious due to the large amount of p-ASA supplement and p-ASA excretion mostly in the form of prototype. That how to improve their utilization efficiency and reduce environmental pollution has become the focus of attention. Based on the characteristics of small size, easy absorption, small dosage, and less excretion of nanoparticle, therefore, p-ASA were processed into nanoparticle (p-Arsanilic acid nanoparticles, p-ASAP). The growth performance , growth-related hormones levels and digestive function in the rats were analysed to study the effect and mechanism of p-ASAP on growth promotion, and the arsenic contents in liver and feces of the rats were detected to study arsenic residues and utilization efficiency of p-ASAP.One hundred and twelve 35-day-old SD rats (56 male rats and 56 female rats) were randomly divided into seven groups, 16 rats per group. The rats in Group A (control group) were fed with basal diet, the rats in Group B, C, D were fed with basal diet supplemented respectively with p-ASAP according to the dosage of 1/20, 1/50 and 1/50 of their LD50, and the rats in Group E, F, G were fed with basal diet supplemented respectively with p-ASA according to the dosage of 1/20, 1/50 and 1/50 of their LD50. The rats w