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prgd复合材料促进周围神经修复的分析word论文
AbstractPeripheralnerveregenerationisdifficultyinclinicaltreatment,especiallythelongnerve defect.Inrecentyears, withthedevelopmentofmaterialscienceandmolecular biology,utilizing artificial nerve conduits, especiallybioactive absorbable nerve conduits to repair nerve defect has attracted muchattention and has agreat potentialforapplication.ThisprojectfocusesonconstructingRGDpeptidesgraftedpoly(glycolicacid- L-lysine-lacticacid)/poly(lacticacid(PDLLA/PRGD/β-TCP)asnovelnerverepairmaterialsto simulateperipheral nerve.Thedegradationpropertysuchas weightloss rateofPRGDpipe materialshavebeenmeasuredbyconductinginvitrodegradationexperiment.Theresults indicatedthatPDLLAexhibitedtheslowestdegradationspeed.Weight loss rateofPDLLAand PRGDfilmwasabout25%and50%respectivelyafter24weeks.PRGDcompositefilm possessed abetter histocompatibilitythan PDLLA.Furthermore,primarySchwanncellswerefirstlyisolatedandthenco-culturedwithPRGD compositematerials.TheadhesionandgrowthofSchwanncellsonthesurfaceofPRGD compositematerialswereinvestigatedtoevaluatethecellbiocompatibilityofPRGDcomposite materials.The results showedPRGD compositematerial exhibited good cell affinity.Inaddition,weconductedanimalexperimentstoevaluatethebiocompatibilityofthePRGD composites.Thesciaticnervedefectmodelofadultratswasconductedinthisexperiment,then thedefectednerveswerebridgedwithPDLLAconduits,PRGDconduitsrespectively.After1,3 monthsoperation,theratswereanaesthetizedandconductedwithfunctionrecoveryevaluation, morphologicalevaluation,histologicalevaluation,electrophysiologicalassaytoevaluatethe recoveryoftheregeneratednerve.TheresultsshowedthatPRGDcompositecouldpromotethe regenerationofdefectedsciaticnerveseffectively andhavethegoodbiocompatibilitytoenhance theregenerationofperipheralnerves.Theefficiencycouldcompetewithautograftgroupand was moreprominent thanPDLLAgroup.Keywords: Schwann cells, nerve regeneration, biocompatibility, PRGD composites,nerve conduitII目录摘要.....................................................
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