12抗精神病药——山东大学药理学英文课件Antipsychiatric drugs.ppt

CHAPTER 20 ANTIPSYCHIATRIC DRUGS Psychotic Disorders 1.Schizophrenia (thinking disorder) 2.Mania (mood disorder) 3.Depression (mood disorder) 4.Anxiety Antipsychiatric Drugs 1.Antipsychotic drugs 2.Antimanic drugs 3.Antidepressive drugs 4.Antianxiety drugs Section 1  Antipsychotic Drugs Schizophrenia Personality change and behavior disorders with environment Positive symptoms: thinking disorder, cognition disturbance, hallucination, paranoia, delusion(妄想） Negative symptoms: disturbance of feeling, discommunication Natures of Schizophrenia Dopamine theory of schizophrenia pathogenesis overactivity of the meso-limbic dopaminergic neurons Natures of Schizophrenia raphetamine：promote DA release and induce Schizophrenia. decrease synthesis and storage of DA can improve the condition DA-R increase in putamen and nucleus accumbens septi Antischizophrenic Agents Phenothiazines（吩噻嗪类） Thioxanthenes(硫杂蒽类） Butyrophenones(丁酰苯类） Others The Main Pathways of DA  and Functions in Brain 1.Nigra-striatum （黑质-纹状体） DA system From A9 of meso-nigrosubstantia to caudate nucleus, putamen. Extrapyramidal function （regulation of movement ） Decrease - PD Augmentation - Chorea （舞蹈症） (irregular,involuntary mucle jerks and impair voluntary activity) The Main Pathways of DA  and Functions in Brain 2. Meso-limbic（中脑-边缘叶）DA system the center of emotion and feeling The Main Pathways of DA  and Functions in Brain 3. Meso-cortical（中脑皮层）DA system Cognition, thinking and consciousness System 2 and 3 augmentation -schizophrenia 4.Tubero-infundibular (结节-漏斗 ) DA system Regulate pituitary hormone release The Main Pathways of DA  and Functions in Brain 5.Area post