355-系统生物学简介.ppt

系统生物学简介这是我在本所做的一次内部讲座幻灯，所引用的图片和部分文字来自网络和发表的论文，仅个别为合作研究的个人交流资料，都没有注明具体的出处，特此说明，一并致谢！冯新港 Systems biology: a new term for an old science A Brief History of Systems Biology Basic Concepts in Systems Biology Basic scientific questions or properties in Systems Biology Basic measurement technologies and experimental methods in systems biology research System Structures Identification System Behavior or Function Analysis Test system for systems biology Host–pathogen systems biology Future directions or open issues in systems biology A Brief History of Systems Biology Two important concepts of biology by the end of the 19th century Reductionist complex situations can be analyzed by reducing them to manageable pieces, examining each in turn, and reassembling the whole from the behavior of the pieces Mechanist All biological behavior was predetermined, forced, and identical between all individuals of a particular species; organisms were thus merely complex machines. A Brief History of Systems Biology from Jan Smuts holism to Ludwig von Bertalanffy’s General Systems Theory Holism (from the Greek Holos, whole) is the theory, which makes the existence of wholes a fundamental feature of the world wholes are more than the sum of their parts the mechanical putting together of their parts will not produce them or account for their characters and behaviour A Brief History of Systems Biology from Jan Smuts holism to Ludwig von Bertalanffy’s General Systems Theory General Systems Theory concepts of organization, non-summative wholeness, control, self-regulation, equifinality, and self-organization, are as valid in the social and behavioral sciences as they are in the biological. This led Von Bertalanffy to postulate a new discipline, its subject matter being the formulation and derivation of those principles which are valid for systems in general. A Brief History of Systems Biology Paradigm shift in biology from component to systems analysis during the l