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Chapter 7
Endomembrane system,
Chapter 7
Endomembrane system, Protein
Sorting and membrane
Protein Sorting and
trafficking
membrane trafficking
1. The Compartmentalization of
Cells
The Structure of a bacterium
All Eucaryotic Cells Have the Same Basic Set of Membrane-
enclosed Organelles
Functions of cytoplasmic matrix
The protein synthesis, degradation and modification.
Cells carefully monitor the amount of misfolded proteins. An accumulation of misfolded
proteins in the cytosol triggers a heat-shock response, which stimulates the transcription
of genes encoding cytosolic chaperones that help to refold the proteins.
2. Endomembrane System
Topological relationships between compartments of the secretory
and endocytic pathways in a eucaryotic cell
Proteins Can Move Between Compartments in Different Ways
Vesicle budding and fusion
during vesicular transport
Signal Sequences and Signal Patches Direct Proteins to the
Correct Cellular Address
Two ways in which a sorting signal can be built into a protein
Claude and G.Palade,1974 Nobel Plrize
The Endoplasmic Reticulum
Membrane-bound Ribosomes Define the Rough ER
Smooth ER Is Abundant in Some Specialized Cells
Rough and Smooth Regions of ER Can Be Separated by Centrifugation
Signal Sequences Were First Discovered in Proteins Imported
into the Rough ER
A Signal-Recognition Particle (SRP) Directs ER Signal
Sequences to a Specific Receptor in the Rough ER Membrane
Figure 12-44 Molecular Biology of the Cell (© Garland Science 2008)
Figure 12-44a Molecular Biology of the Cell (© Garland Science 2008)
Figure 12-44b,c Molecular Biology of the Cell (© Garland Science 2008)
The ER Signal Sequence Is Removed from Most Soluble
Proteins After Translocation
Figure 12-47 (part 1 of 2) Molecular Biology of the Cell (© Garland Sc
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