[医学]Resting-state_fMRI_for_杭州培训班20111111.pdf

Resting-State fMRI: methodology and application ZĀNG Yu-Feng M.D. Center for Cognition and Brain Disorders The Affiliated Hospital Hangzhou Normal University 杭州师范大学认知与脑疾病研究中心 杭州师范大学附属医院 zangyf@ 1 杭州师范大学认知与脑疾病研究中心 杭州师范大学附属医院 2 杭师大认知与脑疾病研究中心 主要特色 • 3T MRI，安装在医院，纯研究型 • MRI-compatible: EEG, eye tracking, 16- channel physiological monitor, fNIRS, TMS • 研究团队：固定研究人员编制约50人 3 Outline • What is resting-state fMRI? • Computational methodology • Applications to brain disorders and cognitive neuroscience 4 MRI Anatomical: T1, T2…… Diffusion Tensor-MRI MRS Perfusion (DSC, ASL…) fMRI-BOLD …… 5 Experimental design for task fMRI • Blocked-design • Fast event-related • Slow event-related • Mixed 6 Task-state fMRI? Contrast within a scanning session is necessary! Every 30 s alternatively T C T C T C Design Expected signal 7 Task-state fMRI What is activation? activated delta baseline or control