[医药卫生]Hepatitis B – Toward Comprehensive Prevention Programs——海斯文.pdf

Hepatitis B – Toward Comprehensive Prevention Programs Stephen Hadler, M.D. 海斯文 WHO China 世界卫生组织驻华代表处 Outline 提纲 • Global Scope of Problem • Epidemiology – Key Aspects • Measuring Effectiveness of Hepatitis B Prevention Programs • Toward Comprehensive Prevention –United States • Perspectives on China Hepatitis B Prevention Hepatitis B Virus Infection 乙型肝炎病毒感染: Worldwide Burden of Disease全球范围的疾病负担 • 2 billion people have serologic evidence of HBV infection 20亿人有血清学感染乙肝病毒的证据 • 350 million people chronically infected 3.5 亿人为慢性感染 − at risk of developing HBV-related chronic liver disease (cirrhosis, hepatocellular carcinoma) 处于发展为乙 肝相关慢性肝脏疾病(包括肝硬化、肝细胞癌）的危险 • 600,000 deaths each year from HBV-related chronic liver disease 每年60万人死于乙肝相关的慢性肝病 Leading Causes of Infectious Disease Deaths Worldwide (2002) 2002年全球传染病主要死因 Disease疾病 Deaths per Year每年死亡数 Lower respiratory tract infections下呼吸道感染 ~3.8 million 380万 HIV/AIDS 艾滋病 ~2.8 million 280万 Diarrheal diseases 腹泻病 ~1.8 million 180万 Tuberculosis 结核病 ~1.6 million 160万 Malaria 疟疾 ~1.2 million 120万 Measles 麻疹 ~760,000 76万 Hepatitis B 乙型肝炎 ~600,000 60万 Pertussis 百日咳 ~300,000 30万 Neonatal tetanus 新生儿破伤风 ~290,000 29万 Intestinal Parasites 肠道寄生虫病 ~130,000 13万 Source: CDC and WHO Geographic Pattern of Hepatitis B Prevalence 乙型肝炎流行地区分布类型图