高血压与血管损伤_高平进演示文稿.ppt

0.44 0.45 0.46 0.47 0.48 0.49 0.50 0.51 0.52 0.53 unadjusted adjusted Non-stroke Stroke 47 48 49 50 51 52 53 54 55 unadjusted adjusted Non-stroke Stroke Figure AASI 24-h PP AASI in hypertensives with and without stroke 2009 ESH post 颈总动脉IMT，本研究中应用PHILIPS HD11EX 超声仪提供的Qlab软件自动测量，IMT0.9mm定义为增厚，IMT1.3mm定义为斑块形成。图a为正常颈总动脉IMT；图b为颈总动脉IMT增厚；图c为颈总动脉粥样硬化斑块形成（箭头所示）。 动脉中内膜厚度(IMT) 基础状态下肱动脉直径图 反应性充血后肱动脉直径图 FMD=(反应性充血后直径- 基础状态下直径)/基础状态下直径 血流介导的血管舒张(FMD) r P value Age(years) -0.235 0.001 BMI(kg/m2) -0.227 0.001 Waist(cm) -0.244 0.001 Waist-Hip ratio -0.200 0.001 hs-CRP(mg/L) 0.063 0.298 TC(mmol/L) -0.043 0.475 TG (mmol/L) -0.083 0.164 HDL-C (mmol/L) 0.186 0.002 LDL-C (mmol/L) -0.034 0.572 Blood-fasting glucose(mmol/L) -0.059 0.314 SBP(mmHg) -0.125 0.036 DBP(mmHg) 0.055 0.355 PP(mmHg) -0.187 0.002 History of hypertension(years) -0.202 0.001 Correlation of FMD with cardiovascular risk factors Xu JZ，et al J human hypertension 2009 Correlation of FMD with target organ damage (TOD) Xu JZ，et al J human hypertension 2009 Characteristics No TOD (n=61) One TOD (n=113) Two TOD (n=59) ≥ThreeTOD (n=47) Age (years) 53±10 59±8** 63±9**? 64±9**? Gender, F/M 28/33 55/58 18/41 17/30 BMI (kg/m2) 24.49±2.57 25.50±2.97* 26.16±3.45** 26.48±2.54** Waist (cm) 85.98±8.15 87.38±8.31 90.10±9.92** 92.55±8.22**? WHR (cm/cm) 0.89±0.05 0.89±0.05 0.91±0.05*? 0.93±0.06**? Smoking, n(%) 19(35.85) 28(24.78) 21(35.59) 22(46.81) *? DM, n(%) 3(4.92) 13(11.50) 5(8.47) 5(10.64) SBP (mm Hg) 129.87±16.63 139.20±14.50** 147.25±17.27**? 158.87±19.50**? DBP (mm Hg) 84.41±11.44 84.39±10.67 86.02±12.49 88.49±12.06? PP (mm Hg) 45.46±11.83 54.81±14.20** 61.24±13.49**? 70.38±16.76**? Hypertension (years) 10.78±8.41 16.58±10.85** 18.07±10.83** 22.49±11.90**? Hs-CRP (mg/L) 1.91±3.60 1.90±2.53 1.64±1.23 2.02±2.23 TG (mmol/L) 2.05±1.33 2.30±1.76 2.15±1.17 2.34±1.61 TC (mmol/L) 4.95±1.06 5.02±1.01 5.11±0.82 5.23±0.81 HDL-C (mmol/L) 1.44±0.35 1.43±0.36 1.39±0.34 1.42±0.37 LDL-C (mmol/L) 2.78±0.74 2.75±0.78 2.93±0.69 2.97±0.6