近十年中药药代动力学新技术新方法概述-环球中医药.PDF

近十年中药药代动力学新技术新方法概述 柏冬摇 王瑞海摇 刘丽梅 揖摘要铱摇 中药具有多成分、药效物质不确切的特征,长期以来中药药代动力学的研究存在许多 困难。 新的仪器、分析技术的出现,提高了中药体内成分分析的灵敏度,使得中药多成分药代研究 成为可能。 目前认为,在中药药代动力学研究中同时监测多个成分的药代动力学特征是十分有必 要的,“中药多组分整合药代动力学研究冶“中药药代标记物冶“代谢组学冶的研究思路较好地解决了 这个问题。 但目前的研究仍然存在许多争议,本文对近十年中药药代动力学的新技术与新方法进 行综述,希望对中药药代动力学研究提供借鉴。 揖关键词铱摇 中药药代动力学;摇 中药多组分整合药代动力学;摇 中药药代标记物;摇 代谢组学 揖中图分类号铱摇 R285.5摇 揖文献标识码铱摇 A摇 doi:10郾3969/ j郾issn郾1674鄄1749郾2016郾07郾040 Review on new technologies and methods of pharmacokinetics of traditional Chinese medicines in recent 10 years摇 BAI Dong, WANG Rui鄄hai,LIU Li鄄mei. 摇 Institute of Basic Theory of TCM, China Academy of Chinese Medical Sciences,Beijing 100700,China Corresponding author:LIULi鄄mei,E鄄mail:liulimeihrb@163.com 揖Abstract铱摇 As the chemical compositions in traditional Chinese medicine is very complex and the effective components are not accurate,there are many difficulties in the study of traditional Chinese medicine. With the developments of new technologies and methods,a lot of achievements in the 基金项目:国家重点基础研究发展计划(973计划)(2012CB518401) 作者单位:100700摇 北京,中国中医科学院中医基础理论研究所 作者简介:柏冬(1983- ),博士,副研究员。 研究方向:中药药效物质基础。 E鄄mail:baidong2000@126.com 通讯作者:刘丽梅(1965- ),女,本科,研究员。 研究方向:中医方证基础研究。 E鄄mail:liulimeihrb@163.com 摇摇892 环球中医药2016年7月第9卷第7期摇 Global Traditional Chinese Medicine,July2016,Vol郾9,No郾7 pharmacokinetics have been made at home. For example,the emergence of new instruments and analysis technology can improve the sensitivity of the analysis the composition of traditional Chinese medicine in vivo,and make itpossibletostudythecompositionoftraditional Chinesemedicine. Ithasbeenreachedan agreement that monitoring multi鄄components爷 pharmacokinetics characteristic at the same time is very necessary. The research idea of “integral pharmacokinetic study of multiple components冶 , “pharmacokinetic markers of traditional Chinese medicine冶 and “metabonomics technology冶 can resolve this problems,but therearestillof alotofcontroversy