[农学]CellBiology细胞生物学Englishcharpt-2.ppt

ECM的特性？？？ 拉不断 collagen 压不碎 proteoglycan 粘得住 fibronectin and laminin RAF:血小板活化因子 catenin 连环蛋白[一类细胞骨架蛋白,分α、β、γ三种] vinculin 粘着斑蛋白,纽蛋白,纽带 fibronectin [?faibrEunektin] [英汉医学名词 6] 纤维连接蛋白 [英汉细胞生物学名词] 纤连蛋白 [英汉生物化学名词] 纤连蛋白 cornea [kO?niE] 角膜 glycosaminoglycans 葡萄糖胺聚糖,氨基葡聚糖 proteoglycans 蛋白聚糖 interstice [intE?stis] 小间隙hydrated gel 水合凝胶 vicinity [visiniti] 附近,邻近 胶原是胞外基质中最主要的水不容纤维蛋白。其基本结构单位 Chondrocyte:软骨细胞chondrocyte [k?ndr?sait] n. 软骨细胞 ECM主要由fibroblast分泌；构成结缔组织的大部分空间； 基膜：将上皮细胞和结缔组织分开；血管内皮细胞下面也有； 主要成份：IV型胶原、蛋白聚糖、层粘连蛋白、巢蛋白（entactin）； Pink: collagen IV; green: laminin; purple: entactin巢蛋白; Lys mutant hinder trilex forming Cell Coat Define: all integral membrane proteins , as well as certain membrane lipids, bear short chains of sugars (oligosaccharides) that project outward from the plasma membrane .These carbohydrate projections form part of a layer closely applied to the outer surface of the plasma membrane called glycocalyx. Cell Coat（细胞外被） Define:细胞外被又称糖萼，指细胞膜外表面覆盖的一层多糖物质，是细胞膜的正常结构组分，对膜蛋白起保护作用，并在细胞识别中起重要作用。 Extracellular Matrix Define: an organized network of extracellular materials that is present beyond the immediate vicinity of the plasma membrane 指分布于细胞外空间，由细胞分泌的蛋白和多糖构成的网络结构 An organized network of extracellular materials that is present beyond the immediate vicinity of the plasma membrane. Fibrous network as scaffolds, girders, wire and glue! The extracellular matrix (ECM) For an example Basement membrane (basal lamina) A 50-200nm thick sheet 1) surrounds muscle and fat cells 2) underlies the basal surface of epithelial cells 3) underlies endothelial lining of blood vessels. ECM species Collagen 胶原蛋白 A family of insoluble fibrous glycoproteins that are present only in animal extracellular matrices. resist pulling forces Gly-X-Y repeat in primary structure X: often pro Y: often hypro or hylys; lys important Figure?2-32?Scanning electron micrograph of fibroblasts in connective tissue.?The tissue is from the cornea（角膜） of