磷脂脱酰作用与甘油磷酸二脂的运输代谢合成的影响.pdf

Biochimica et Biophysica Acta 1771 (2007) 337 – 342 /locate/bbalip Review Transport and metabolism of glycerophosphodiesters produced through phospholipid deacylation Jana Patton-Vogt ⁎ Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA Received 14 March 2006; received in revised form 20 April 2006; accepted 26 April 2006 Available online 6 May 2006 Abstract Phospholipid deacylation results in the formation of glycerophosphodiesters and free fatty acids. In Saccharomyces cerevisiae, four gene products with phospholipase B (deacylating) activity have been characterized (PLB1, PLB2, PLB3, NTE1), and those activities account for most, if not all, of the glycerophosphodiester production observed to date. The glycerophosphodiesters themselves are hydrolyzed into glycerol-3-phosphate and the corresponding alcohol by glycerophosphodiester phosphodiesterases. Although only one glycerophosphodiester phosphodiesterase-encoding gene (GDE1) has been characterized in S. cerevisiae, others certainly exist. Both internal and external glycerophosphodiesters (primarily glyceropho- sphocholine and glycerophosphoinositol) are formed as a result of phospholipid turnover in S. cerevisiae. A permease encoded by the GIT1 gene imports extracellular glycerophosphodiesters across the plasma membrane, where their hydrolytic products can provide crucial nutrients such as inositol, choline, and ph