眼科门诊干眼的流行病学调查及相关危险因素分析.doc

眼科门诊干眼的流行病学调查及相关危险因素分析 ? 214? 眼科新进展2008年3月第28卷第3期 RecAdvOphthalmolVo1.28No.3March2008 眼科门诊干眼的流行病学调查及相关危险因素分析 张宏安晓陈雪艺 Prevalenceandriskfactorsas- sociatedwithdryeyeinahos- pital-basedpopulation ZHANGHong.ANXiao,CHENXue-Yl 【Keywords】dryeye;epidemiologicalinvestiga- tion;riskfactor 【Abstract】ObjectiveTostudytheW~d]enceof dryeyeinahospital-basedpopulationandtoevaluate theriskfactorsattributabletodryeye.MethodsA totalof650newoutpatientsageabove30yearswere screenedfordryeyefromApriltoJune2005andS tembertoNovember2005.Arinformedconsentwas obtainedfromsul~’ects.aquestiounJdrewerenscd, whenaresI~ondentindicatedthepresenceofsymp? tom.breakuptiIne(BUT)testwasperformed.Sub一 {eetswhosethevalueofBUTlt;l0secondswereunder— gonethedryeyetestincluding:fluoresceinstailling test.meibomianglandfimction.SchirmerItest,rose bangle;Thenahospitol-basedcase.controlstudywas conductedtothosesubiectswhoweredeemedtobe suffering矗砌dryeye.twomatchedcontrolsperdry eyecasewererandomlyselected.Multivariatecondi— tionalLogisticregressionmodelwasusedforunivari? ableandmultivariateanalysis.ResultsSixhundred andfiftypeopleparticipated;Theyrangedinagefrom 3083years(withameanof49.9years).Dryeyewas presentin134(2O.6%)ofthestudysub.it?. iectswassig niflcantlyhi~her(Plt;0.001)infemales(26.2%)than inmale(15.0%);Dry一_eyeprevalenceincreasedpro gressivelywithage.itwashigherinthoseabove60 yearsofagethaninyongers(Plt;0.05),dryeyepreva? lencemhlj瑚uminthose30years(11.1%):Onanaly? singthepresentingcomplaints,themostco1111TIon complaintwasdryne88.foundin182(28.0%)subjects, followedbyocul~fatigue158(24.3%)andthemost leastcomplaintwas0culaurpainin42(6.5%).In650 subiectsthemeanvalueofBUTwas(9.50±2.86)sec? onds.InmalethemeanvalueofBUTwasfl0.22± 2.30)seconds.whichwasstgnfficanthigherthanthat infemale(8.76±3.16)seconds(Plt;0.001).BUrde? reasedprogressivelywithage,inthoselow60yearsof 收稿日期:20074)6-22修回日期:2007—11-24本文编辑:徐刚珍 作者简介:张宏,女,1969年1月出生,辽宁省瓦房店人,硕士,主治医 师.联系电话E—mail:xjophth’,~@163.corn,MJZ.moon@ yahoo.tom 作者单位:8