姜黄素 双胍基氨基酸钠衍生物的合成及电 化学性质毕业论文.doc

大连民族学院本科毕业论文 姜黄素-双胍衍生物及电化学性质 学院（系）：生命科学学院 专业：应用化学 学生姓名： 学号： 2010034226 指导教师：刘巨涛教授 评阅教师： 完成日期： 2014年6月 大连民族学院  姜黄素作为一种有效的抗癌剂，抗肿瘤谱广、多靶点、能逆转肿瘤多药耐药性。尤其是姜黄素确切的抗肿瘤活性、简单的结构及易于合成、改造的优点，使之成为受人关注的药物开发先导物。合理地进行姜黄素的结构衍生化，实现结构和优良性能的有效结合一直是姜黄素应用研究的热点问题。深入研究和开发姜黄素类药物具有重要理论和现实意义，不但能丰富对重大疾病发生、发展过程的理解和认识，为新药创制提供新的备选化合物，还能为姜黄素类化合物的应用研究奠定基础，研究成果应用后将产生巨大的经济和社会效益。 本文以甘氨酸、丙氨酸、甲硫氨酸、双氰胺和姜黄素为基本原料，合成了3个姜黄素双胍基氨基酸钠衍生物，经红外光谱和核磁共振波谱等方法进行了结构表征，证明所得产物为目标化合物。并对姜黄素-氨基酸钠双胍衍生物的电化学性质进行了研究。 关键词：姜黄素；双胍；氨基酸钠；合成；电化学性质 Synthesis and properties of the curcumin derivatives of biguanidino amino acid sodium Abstract Curcumin, as a potent anticancer agent, has anti-tumor spectrum and multi-target and can reverse multidrug resistance. In particular, it is concerned that the Curcumin can be regarded as the leading compounds in drug development beacause of the exact anti-tumor activity of curcumin, a simple structure and easy synthesis. The structure of curcumin ismodified in a reasonable manner, in order to achieve an effective combination with its structure and excellent performance, which has been a hot issue of curcumin.Deeply research and development of curcumin drugs has important theoretical and practical significance, which can not only enrich occurrence, understanding and awareness of major diseases, and offers new alternative compounds for the development process of new drug, but also lay the foundation for the application of curcumin derivatives, and application of research results will bring a huge economic and social benefits. In this paper, glycine,alanine,methionine,dicyandiamide and curcumin as basic raw materiais, we synthesized three curcumin guanidine amino acid sodium derivatives, by infrared spectroscopy and nuclear magnetic resonance spectroscopy for the characterizaton of the structure, indicate that the products of target compounds. And the electrochemical properties of curcumin--amino acid sodium guanidine derivatives were studied. Keywords:Curcumin, biguanide, amino acid sodium,