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中国新诊断2型糖尿病初始治疗方案的探讨4844924
HDL-C 相对于基线变化值 P=0.0243 P=0.0747 1.23 1.24 1.23 1.24 Baseline *ITT人群和PP人群结果一致; 表中数据为LS mean (最小均方差) Yang WY,et al.The Lancet Diabetes Endocrinology, Early Online Publication, 18 October 2013. 胰岛素相对于基线变化值 – ITT人群 0min 30min 120min 180min ? ? ? ? ? ? ? ** ** ** ? ? ? ? ? ? ? ? mean insulin(uIU/mL) ? 治疗24周和48周后,两组餐后胰岛素水平都降低, 且阿卡波糖明显优于二甲双胍 **p0.01 between two groups ? p0.05, ? p0.01, compared with baseline Baseline (week 0) data are means. Post treatment (week 24 and 48) data are LS means. Acarbose Metformin 0min 30min 120min 180min Yang WY,et al.The Lancet Diabetes Endocrinology, Early Online Publication, 18 October 2013. β细胞功能 (HOMA-B) -ITT人群 HOMA-B=20*FINS/(FPG-3.5); 表中数据为LS mean; *p值为两组相对于基线差值比较结果 *P=0.9113 Acarbose(week0) Acarbose(week24) Acarbose(week48) Metformin (week0) Metformin(week24) Metformin(week48) *P=0.9685 Yang WY,et al.The Lancet Diabetes Endocrinology, Early Online Publication, 18 October 2013. P=0.5268 P=0.2167 HOMA-IR=FINS*FPG/22.5; 表中数据为LS mean; *p值为两组相对于基线差值比较结果 胰岛素抵抗(HOMA-IR)–ITT人群 Acarbose(week0) Acarbose(week24) Acarbose(week48) Metformin (week0) Metformin(week24) Metformin(week48) Yang WY,et al.The Lancet Diabetes Endocrinology, Early Online Publication, 18 October 2013. *p0.05 between two groups ? p0.05, ? p0.01, compared with baseline Baseline (week 0) data are means. Post treatment (week 24 and 48) data are LS means. ? ? ? ? ? ? ? ? ? ? ? * 胰高糖素相对于基线变化值 – ITT人群 0min 30min 120min 180min mean glucogan(pg/mL) ? Acarbose Metformin 0min 30min 120min 180min Yang WY,et al.The Lancet Diabetes Endocrinology, Early Online Publication, 18 October 2013. ? p0.01, compared with baseline Baseline (week 0) data are means. Post treatment (week 24 and 48) data are LS means. Mean plasma GLP-1 (pM) ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 活性GLP-1相对于基线变
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