医学--弥漫性肺间质性疾病.ppt

* Photomicrograph of AIP, showing the characteristic, temporally uniform thickening of alveolar septa by a mixture of mononuclear cells. Although the size of the air spaces and the degree of interstitial thickening vary from one area to another, the component cellular infiltrate remains constant. Hematoxylin and eosin; original magnification: ×120.  * Higher-magnification view of an alveolus in AIP, showing that most of the alveolar septal thickening is due to the presence of oval to spindle-shaped fibroblasts and a few scattered small lymphocytes. Alveolar pneumocyte hyperplasia along the alveolar walls is prominent as well. Hematoxylin and eosin; original magnification: ×480.  * Figure 9c.??Organizing phase of acute interstitial pneumonia in a 55-year-old man. (a) High-resolution CT scan demonstrates diffuse ground-glass attenuation, bronchiectasis, and bronchiolectasis (arrows). (b) High-resolution CT scan demonstrates diffuse ground-glass attenuation. A small amount of honeycomb lung affects the anterior part of the middle lobe (arrow). Small patches of consolidation affect the left lower lobe peripherally. (c) In the organizing phase, proliferative fibroblasts solidify the lung as they destroy alveolar architecture. Photomicrograph (original magnification, x50; hematoxylin-eosin stain) shows fibrin (a) filling a few residual alveoli (b). Pneumocytes are hyperplastic (c). d = alveolar septa.  * Figure 2a.??Nonspecific interstitial pneumonia in a 74-year-old woman. (a) High-resolution CT scan demonstrates bilateral, subpleural ground-glass attenuation. There are irregular linear areas of high attenuation (arrowhead) and evidence of architectural lung distortion with distortion of the left fissure (arrow). Follow-up CT in 7 months demonstrated no interval change. (b) Photomicrograph (original magnification, x12.5; hematoxylin-eosin stain) reveals alveolar architecture that is altered by interstitial fibrosis (a), all of which is approximately the same ag