多不饱和脂肪酸对细胞膜功能影响的研究进展.pdf

生物技术通报 BIO TE CHN OLOG Y B ULLETIN 200 9 12 李喜艳 王加启 卜登攀 魏宏阳 胡菡 周凌云 ( , 100 193) : 多不饱和脂肪酸是细胞膜磷脂的重 组成成份, 影响细胞膜的稳定性它具有广泛的生物学功能, 包括细胞 内信号传导通路基因表达和细胞凋亡的调控等主 从细胞膜脂质的组成, 细胞膜的流动性及膜脂质过氧化等方面对多不 饱和脂肪酸对细胞膜功能的影响进行了综述 : 多不饱和脂肪酸 细胞膜 功能 Advanced R esearch of E ffect of Polyunsaturated Fatty A cids on CellM em brane Function L i X iyan W ang Jiaq i Bu D engpan W eiH ongyang H u H an Zhou L ingyun (S ta teK ey L a bora tory of A n mi a lN utrition, Institute of A n mi a l S cience, Ch inese A cad emy of Ag ricultura l S ciences, B e ij ing 100193) A bstrac:t P olyunsa ura ed fa y acids are an mi por an componen o f ce llm em brane phospho lipids, and asso cia ed w i h ce llm em- brane s ab ili y. I is w ide ly involved in b io log ical func ions such as cell signa ling pa hw ays, gene expression and ce ll apop osis. T he ob- jec ive o f h is pape r is o overv iew he effec o f po lyunsa ura ed fa y ac ids on func ion of ce ll m embrane, w h ich m a in ly focu ses on he m em brane lip id com posi ion, m em brane flu id i y, and membrane lipid perox ida ion. K ey w ords: Po lyunsa ura ed fa y ac ids C ellm em brane Func ion , 1 , [ 1] ( poly unsa ura ed fa y acids, , PU FA ) , , -3-6 -3 3 PU- FA, ( EPA ) , , ( DHA) -( ALA ) -6