大仁科大讲义.pdf

Introduction The Design of Dosage ： From The View of Pharmaceutical RD 趙彥欽 台北醫 學大學藥 學系藥劑組博士 健喬信元醫藥生技股份有限公司副廠 長 藥學組  工業藥學  製劑工程 臨床藥學組 調劑藥師 臨床藥師 臨 床藥師前途 ?? 國人的用藥觀念 臨床 專科( )藥師執照制度的建 立 住 院藥師制度?  政府的健保及醫院評鑑政策  提升臨床專業  與醫師劃分專業 提供醫師及病人諮詢服務  持去教育不斷自我學習新知 Medicine is Poison?? Diseases requirement Patient`s compliance raised Drug design to Extended dosing interval Potency increased Easy to use Fast absorption Formulation study base on Penetration enhanced pharmacokinetics Adverse(side) effect Absorption decreased Distribution Low dose Metabolism Focus on lesion Elimination Localize administration Drug Administration Absorption Pathway for The Oral Drug  Stomach  Disintegration  Gastric juice  Drug damage  Small Bowel  Dissociation state  Active Transport  Passive transport  Permeabi