7螺旋束膜蛋白组成一个共同的结构？.pdf

Volume 148,number 2 FEBS LETTERS November 1982 Review Letter Rhodopsin and bacteriorhodopsin: structure-function relationships Yu. A. Ovchinnikov Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow, USSR Received 13September 1982 Rhodopsin structure Bacteriorhodopsin structure Photoreception Light transformation Integral membrane protein Retinal Photoreception and light transformation by liv- gradient of H+ turned out to be a universal ener- ing systems undoubtedly belong to the most sur- getic source for the cell. Interestingly, full proton- prising natural phenomena. Along with low-M, pumping activity has been restored after complete chromophoric compounds, specific proteins play delipidation and following reconstitution of bacte- an important part in absorption and transduction riorhodopsin into liposomes [ 16-l 81. of light energy. Among photosensitive proteins, Bacteriorhodopsin was the first integral mem- rhodopsin occupies a key position. This chromo- brane protein the structure of which was eluci- protein, with 1l-cretinal as a photoreceptor dated. Henderson and Unwin, in their pioneering antenna, is the basis of the vision