TheRelationshipofPSA__省略_ntswithProstate.pdf

318 Chinese Journal of Clinical Oncology Oct. 2007, Vol. 4, No. 5 P 318~321 Shaojun Nong et al. [SpringerLink] DOI 10.1007/s11805-007-0318-y The Relationship of PSA, PSAD and Clinicopathologi- cal Stage in Patients with Prostate Cancer Shaojun Nong OBJECTIVE To investigate the relationship between the clinicopatho- Duangai Wen logical stage and serum prostate specific antigen (PSA) concentration and Caibin Fan PSA density (PSAD) in patients with prostate cancer. METHODS The clinicopathological stage was determined on the basis of a pathological examination and clinical data in 65 prostate cancer patients treated by radical prostatectomy. PSA and PSAD were measured before the operation. The Spearman rank correlation was applied to evaluate the rela- tionship between the clinicopathological stage, serum PSA concentration and Department of Urology, the First Affiliated PSAD. Hospital of Suzhou University, Suzhou RESULTS Patients with higher PSA and PSAD were significantly more 215006, China. likely to have higher clinical stages, a higher Gleason score, positive surgical margins, capsular penetration, and seminal vesicle invasion (each P0.05). But there was no significant association between PSA and lymph node me- tastasis (P=0.053)