(精选)【医学课件课件大全】 针刺镇痛研究教学课件.ppt

针刺镇痛成果 继续延伸 1990 用于“戒毒” Drug addicts in China (million) 80% - 85% heroin addicts 0 0.2 0.4 0.6 0.8 1.0 1990 1993 1997 2000 2002 2003 An increase of 14 folds in 14 years 1.05 Registered drug addicts in China ( million ) 0.07 脑内一闪念 如果针刺引起脑内释放吗啡样物质, 为何不利用这类物质 －减轻戒断症状（身体依赖） －压制强烈心瘾（精神依赖） 药物成瘾 身体依赖：戒断症状， 来势凶猛 精神依赖：渴求，心瘾，极难解决 Effect of HANS on heart rate of heroin addicts Day of treatment 1 2 3 4 5 6 7 8 9 10 60 70 80 90 100 110 120 130 Control 2 Hz 2/100 Hz 100 Hz n=13-16 * * * * * * * * * Heart Rate (beat/min) 100 Hz 2 Hz Body Weight (kg) 0 1 2 3 4 5 6 7 8 9 10 11 Days of Treatment 45 50 55 60 Control 2Hz 2/100Hz 100Hz (n=26-32) Effect of HANS on Body Weight during Opiate Withdrawal * * * * * * * ** ** ** Can HANS suppress heroin withdrawal syndrome? To reduce the dose of BPN needed for heroin detoxification BPN Dose (mg/d) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Days of Treatment 0.0 0.5 1.0 1.5 2.0 2.5 ** ** ** ** ** Buprenorphine HANS + BPN ** P0.001, compared with BPN group 100 : 8.3 HANS t.i.d HANS b.i.d HANS q.d 药物成瘾 身体依赖：戒断症状， 较易解决 精神依赖：渴求，心瘾，极难解决 The computer- controlled conditioned place preference (CPP) experimental system A B C 52 条件性位置偏爱 实验装置 Conditioned place preference (CPP) Naloxone Reversible Effect n=8~9 0.0 2.5 5.0 7.5 10.0 *** 2 Hz EA NS NX 1 Needle control Control Restraint Foot shock Needle 100Hz 2Hz 2/100Hz 0.0 2.5 5.0 7.5 10.0 *** *** Time Spent in the Drug-pairing Side (min) n=18~20 Frequncy: 2 Hz 100 Hz EA suppression of morphine CPP 21 2 Hz 100 Hz 脱毒 （抑制戒断症状） 防复吸 (抑制心瘾) 100 Hz 2 Hz 2 Hz 100 Hz 22 电针或HANS 治疗海洛因成瘾 HANS 抑制心瘾的最优频率 Days of observation Drug use over 1 year (aver 4.6 y); Detoxification over 1 month; Male, Aver 25 y; n=29-30 Craving score (VAS) 30 min per day Pre-HANS HANS-treating Post-HANS 10 20 30 100 Hz 2 Hz Mock 2/100 Hz 0 0 1 2 3 4 5 2 Hz 100 Hz 电针方法 是否有改进余地？ 穴位接受什么刺激？ 机悈刺激: 机悈压迫(砭）,针刺 温度刺激：温针(经针)，灸(经皮) 电刺激 ：经针(电针)，经皮(TENS) 电刺激穴位：两种方式 经针 (电针， EA) 0.5 - 3.0 mA 经皮 (经皮电刺激，TENS) 5 -