(精选)【医学英文课件】 Cytokines and Lymphocyte Subsets教学课件.ppt

Cytokines and Lymphocyte Subsets Micro 204 Rich Locksley Nov 2016;;;Cytokine functions;Cytokine Function - Examples;Cytokine biosynthesis - general features;Cytokine headaches;Cytokine headaches;;;;;;;;;;;;Common paradigms underpinning redundancy;Combinatorial use underpins cytokine redundancy;Combinatorial use underpins cytokine redundancy;Combinatorial – but engagement sequence matters;;Combinatorial – but receptors matter;;;SOCS proteins: negative regulators of cytokine SFRs;;Therapeutic Potential of Cytokines;;Critical early concepts driven by Th1/Th2 paradigm;Th1/Th2 - definitions;TSLP;Th subsets: an epigenetic differentiation model;Conserved Noncoding Sequences in the type 2 cytokine cluster on chromosome 11 (5q) Bold = Single-copy * = conserved in human, mouse, rat, rabbit, dog, cow, pig, chicken, fugu ;;;KM Ansel et al, An epigenetic view of helper T cell differentiation. Nature Immunol 4:616-623, 2003.;Tissue-specific expression regulated by incorporation of LCR and induction of lineage-specific factors;;Initiation of Transcription Stabilization Hardwired;Th2;;IL-21;;;;;;;;;Tissue IL-13-secreting cells are Th2 effector cells; ;Th subsets coordinate distinct populations of innate cells that share effector functions;Innate Lymphoid Cells, 2016 Lineage-negative, Id2-dependent cells that arise from a common lymphoid precursor. Comprise cells that mediate lymph node organogenesis during fetal development and become tissue-resident effector cells expressing cytokine programs driven by transcriptional modules associated with typical CD4 helper subsets (Th1, Th2, Th17, etc). Roles in homeostasis (establishing commensals, responding to dietary signals, responding to circadian cues, etc). Roles in inflammation and disease (facilitate programs mediated by established Th subsets). ;;‘Innate’ TCR+ lymphoid cells ;McDonald BD et al., Nature Immunol 14:1110, 2013 ;Cell 164:1198, 2016;Cell 150:1235-48, 2012;Kastenmuller W…RN Germain