药学毕业论文--布洛芬对急性上呼吸道感染患儿的退热效果.doc

布洛芬对急性上呼吸道感染患儿的退热效果 【关键词】 布洛芬；对乙酰氨基酚；退热；儿童 　　［摘要］ 目的：观察布洛芬混悬液的退热效果。方法：选择有高热症状的急性上呼吸道感染患儿100例，随机分为两组，分别用布洛芬混悬液（56例）和对乙酰氨基酚口服溶液（44例）治疗，记录首次给药后0.5、1.0、1.5、2.0、3.0、4.0、5.0和6.0 h的体温变化。 结果：布洛芬组和对乙酰氨基酚组体温降低1.5 ℃所需的平均时间分别为（110±78）min、（119±82）min，比例分别为83.9%和84.1%（Pgt;0.05）。体温恢复正常时间分别为（110±76）min、（124±78）min（Pgt;0.05），比例分别为87.5%和68.2%（Plt;0.05）。前2 h两组体温下降相似，在3.0、4.0、5.0和6.0 h布洛芬组平均体温下降大于对乙酰氨基酚组，体温正常化维持时间更长。结论：布洛芬退热疗效优于对乙酰氨基酚。 　　［关键词］ 布洛芬；对乙酰氨基酚；退热；儿童 　　Antipyretic effectiveness of ibuprofen suspension in children with acute upper respiratory infection 　　［Abstract］ Objective:To observe the antipyretic effectiveness of ibuprofen and acetaminophen. Methods: One hundred febrile children, suffered acute upper respiratory infection, were randomized into ibuprofen (56) and acetaminophen (44) groups. Temperature was recorded at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, 6.0 hours after drug administration. Results: The average time for 1.5 ℃ decrease in the temperature was (110±78) min with ibuprofen versus (119±82) min with acetaminophen. The proportions, respectively, were 83.9% and 84.1% (Pgt;0.05). Temperature normalization times were (110±76) min in the ibuprofen group compared with (124±78) min in the acetaminophen one (Pgt;0.05). Temperature normalization rates in the ibuprofen group (87.5%) were significantly higher than the acetaminophen group (68.2%, Plt;0.05). The decline in temperature of two groups was not significantly different during the first two hours. At 3.0, 4.0, 5.0 and 6.0 hours after the first dose of treatment, the mean temperature in the ibuprofen group was significantly lower than the acetaminophen group, demonstrating longer temperature normalization with ibuprofen. Conclusions: The antipyretic effectiveness of ibuprofen was better than that of acetaminophen. 　　［Key words］ Ibuprofen; Acetaminophen; Antipyretic effectiveness; Children 　　布洛芬和对乙酰氨基酚是儿童常用的解热镇痛药，我们对高热患儿分别应用布洛芬混悬液（以下简称布洛芬）与对乙酰氨基酚口服溶液（以下简称对乙酰氨基酚）进行治疗，观察两药的退热效果，现报道如下。 　　1 资料与方法 　　1.1 一般资料2004年8月～2004年1