治疗血液系统疾病的药物.ppt

Inhibitors of blood platelet function The glycoprotein Ⅱb/Ⅲa inhibitors are a new class of antiplatelet angents for use in patients with acute coronary syndromes. These drugs targent the platelet Ⅱb/Ⅲa receptor complex. Inhibitors of blood platelet function The Ⅱb/Ⅲa complex functions as a receptor mainly for fibrinogen and vitronectin but also for fibronectin and von Willebrand factor. Activation of this receptor complex is the “final common pathway” for platelet aggregation. Inhibitors of blood platelet function There are approximately 50,000 copies of this complex on the platelet surface. Persons lacking this receptor have a bleeding disorder called Glanzmann’s thrombasthenia. Inhibitors of blood platelet function Abciximab, a humanized monoclonal antibody directed against the Ⅱb/Ⅲa complex, is the first agent approved in this class of drugs. Used in percutaneous coronary intervention and in acute coronary syndromes. Inhibitors of blood platelet function Eptifibatide is an analog of the sequence at the extreme carboxyl terminal of the delta chain of fibrinogen, which mediates the binding of fibrinogen to the receptor. Inhibitors of blood platelet function Tirofiban contains the amino acid sequence Arg-Gly-Asp (RGD), which is the main recognition sequence for integrin receptors such as Ⅱb/Ⅲa. Drugs are administered parenterally. Fibrinolytic drugs Streptokinase, SK Urokinase, UK Tissue-type plasminogen activator, t-PA Anistreplase Drugs promoting thrombus formation Vitamin K Thrombin and others Antifibrinolysin P-aminomethylbenzoic acid, PAMABA Tranexamic acid, AMCHA Drugs used in anemias Ferrous sulfate Ferric ammonium citrate (枸橼酸铁铵) Iron dextran (右旋糖酐铁) Folic acid Vitamin B12 Drugs used in anemias Erythropoietin, EPO Epoetin-? Granulocyte colony-stimulating factor, G-CSF Filgrastim Drugs used in anemias Granulocyte-macrophage colony-stimulating factor, GM-CSF Sargramostim Dextran (middle molecular weight, low molecular weight) 治疗血液系统疾病的药物Drugs used to t