(人体血吸虫)学习研究.ppt

Intradermal test(IDT) antigen--adult worm antigen(AWA) sensitivity95% false positive rate 2% two weeks after infection early diagnosis(or for new infection) screening test 2. Immunodiagnosis Antibody detection(in sera) sensitivity 95% specificity higher(false positive 2-3%) can’t distinguish between past and active inf. Diagnosis for new infection Epidemiology Methods: COP, IHA, ELISA 2. Immunodiagnosis Antigen detection Cag, maybe distinguish current past infection evaluating the effect of drug Dot-ELISA/Sandwich ELISA monoclonal antibody(McAb) sensitivity 84.5%( 29.0-85.0%) false positive rate 3.1% 2. Immunodiagnosis 4. Altrasound examination for advanced case, e.g. hepatomegaly splenomegaly Network pattern (网状结构) was found in elder cases with history of repetitive and long term infection of S. japonicum Thickening of the portal vein wall was also commonly found in S. japonicum infection. B Altrasound examination √Distribution Mainland of China, Japan, the Philippians, Indonesia. Japan has controlled Schistosomiasis since 1978 √ In China 12 provinces in the south part 391(381) endemic counties 79 million people in endemic areas 14.8 billion square meters snail ridden Epidemiology of S.japonicum Hubei, Hunan, Jiangxi, Anhui, Jiangsu, Sichuan Yunnan Shanghai, Guangdong, Fujian, Guangxi Zhejiang √Types of endemic areas Marshy type(江湖洲滩型): still serious Hubei, Huana, Jiangxi, Anhui, Jiangsu 82.1% infested snail areas Mountainous and hilly type(山丘型) Sichuan, Yunnan Water-net type(水网型) controlled Shanghai(1985), Guangdong(1985), Fujian, Guangxi Zhejiang controlled Detection of Infested water by mice √ Epidemic features Main reservoirs of infection: water buffaloes pigs 31 species wild mammals Ways to infection: contac