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Crystallization of Organic Compounds An Industrial Perspective推荐
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More information from /reports/1058480/
Crystallization of Organic Compounds: An Industrial Perspective
Description: Filled with industrial examples emphasizing the practical applications of crystallization
methodologies
Based on the authors hands-on experiences as process engineers at Merck, Crystallization of
Organic Compounds guides readers through the practical aspects of crystallization. It uses plenty of
case studies and examples of crystallization processes, ranging from development through
manufacturing scale-up. The book not only emphasizes strategies that have been proven
successful, it also helps readers avoid common pitfalls that can render standard procedures
unsuccessful.
The goal of this text is twofold:
- Build a deeper understanding of the fundamental properties of crystallization as well as the
impact of these properties on crystallization process development.
- Improve readers problem-solving abilities by using actual industrial examples with real process
constraints.
Crystallization of Organic Compounds begins with detailed discussions of fundamental
thermodynamic properties, nucleation and crystal growth kinetics, process dynamics, and scale-up
considerations. Next, it investigates modes of operation, including cooling, evaporation, anti-
solvent, and reactive crystallization. The authors conclude with special applications such as
ultrasound in crystallization and computational fluid dynamics in crystallization. Most chapters
feature multiple examples that guide readers step by step through the crystallization of active
pharmaceutical
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