metal-catalyzed α-arylation of carbonyl and related molecules novel trends in c xf8ff;c bond formation by c xf8ff;h bond functionalization文档.pdf

Reviews T. J. Colacot and C. C. C. Johansson DOI: 10.1002/anie.200903424 a-Arylation Metal-Catalyzed a-Arylation of Carbonyl and Related Molecules: Novel Trends in CC Bond Formation by C H Bond Functionalization Carin C. C. Johansson and Thomas J. Colacot* Keywords: a-arylation · CC coupling · carbonyl compounds · homogeneous catalysis Angewandte Chemie 676 2010 Wiley-VCH Verlag GmbH Co. KGaA, Weinheim Angew. Chem. Int. Ed. 2010, 49, 676 – 707 Angewandte a-Arylation Chemie a-Arylated carbonyl compounds are commonly occurring motifs From the Contents in biologically interesting molecules and are therefore of high 1. Introduction 677 interest to the pharmaceutical industry. Conventional procedures for their synthesis often result in complications in scale-up, such as the 2. a-Arylation of Ketones 678 use of stoichiometric amounts of toxic reagents and harsh reaction conditions. Over the last decade, significant efforts have been 3. Palladium-Catalyzed a-Arylation directed towards the development of metal-catalyzed a-arylations of of Esters 687 carbonyl compounds as an alternative synthetic approach that