metal-free oxidative c xf8ff;c bond formation through c xf8ff;h bond functionalization文档.pdf

DOI: 10.1002/chem.201502005 Minireview CH Activation Metal-Free Oxidative CC Bond Formation through CH Bond Functionalization Rishikesh Narayan,[a] Kiran Matcha,[a, b] and Andrey P. Antonchick*[a, c] Chem. Eur. J. 2015, 21, 14678 – 14693 14678 2015 Wiley-VCH Verlag GmbH Co. KGaA, Weinheim Minireview Abstract : The formation of CC bonds embodies the core of need for prefunctionalization of both substrates. This Minire- organic chemistry because of its fundamental application in view is dedicated to the field of CC bond-forming reactions generation of molecular diversity and complexity. CC bond- through direct CH bond functionalization under completely forming reactions are well-known challenges. To achieve this metal-free oxidative conditions. Selected important develop- goal through direct functionalization of CH bonds in both ments in this area have been summarized with representa- of the coupling partners represents the state-of-the-art in or- tive examples and discussions on their reaction mechanisms. ganic synthesis. Oxidative CC bond formation obviates the 1. Introduction are being actively pursued presently, the focus has been to de- velop transition metal-free reactions and reactions that avoid Among various types of chemical reactions, CC bond forma- the use of any metal. tion is probably the most fundamental way of generating mo- Recent years have seen a surge in the interest