少见原因引起的颅内静脉窦血栓形成 课件.ppt

Natural history of cerebral vein thrombosis: a systematic review;Mortality The mortality rate during the acute phase was assessed in 12 Studies,Of 1180 evaluated patients, 66 died within the first month (mean, 5.6%; range, 0%-15.2%). However, the mortality rate varied highly between the studies and was 0 in 5 studies. Of 45 evaluated patients, 32 died as a consequence of CVT (most of them for cerebral herniation), whereas most of 13 died as a consequence of an underlying disease. The overall mortality rate at the end of follow-up was 9.4% (122 deaths in 1303 total patients). However, it was highly variable between the studies (range, 0%-39%). Noteworthy,most of the deaths that occurred during follow-up were related to an underlying condition such as cancer (24 of 38 evaluated deaths during follow-up), and they were not a direct consequence of cerebral vein thrombosis ;Disability Outcome information was available for 8 studies at 3 to 6 months of follow-up and 11 studies at one or more years of follow-up . Eight hundred and fortythree patients provided data at 3 to 6 months of follow-up; 735 surviving patients (87.2%; range, 58.9%-96.4%) had a good outcome with complete or partial recovery, and 73 patients (8.7%;range, 3.6%-29.4%) had a poor outcome with permanent neurologic deficits. At 12 or more months, 12 studies evaluated 1100 patients. Among these, 972 (88.3%; range, 54.2%-97.1%) had a complete or partial recovery, and only 107 (9.7%; range, 0%-45.8%) had a poor outcome ;Recanalization Five studies investigated the recanalization of cerebral venous thrombosis. Unfortunately, all these studies presenting data on recanalization have a relatively small sample size (ranging from 16 to 40 patients) and, in total, enrolled 154 patients. Four of these defined recanalization as complete (blood flow without any interruption), partial (small interruption of continuous blood flow and/or narrowing of the venous lumen), or absent (interrupted blood flow), and the othe