血管生成相关因子在肿瘤中的表观遗传学变化-tumor-肿瘤杂志.PDF

肿瘤2012 年4 月第32 卷第4 期　TUM OR Vol. 32, April 2012　　 301 DOI : 10.3781/j .issn.1109-072 1.2012 .04.014 Copyright© 2012 by TUM OR Review 综述 · 血管生成相关因子在肿瘤中的表观遗传学变化 吕天娇 ，冯炜炜 复旦大学附属妇产科医院妇产科，上海200011 [摘要]　在肿瘤的发生、发展和转移过程中，新生血管的生成起着至关重要的作用，此过程受到相关血管生成因 子的调控，这种调控既包括遗传学方面的，也包括表观遗传学方面的。与遗传学的变化不同，表观遗传学变化大 多是可逆的。研究者正试图应用DNA 甲基化转移酶抑制剂和组蛋白去乙酰化酶抑制剂来拮抗肿瘤及其血管的生成， 从而指导肿瘤的临床治疗。本文综述了近年来受表观遗传调控的肿瘤血管生成相关因子的研究进展，阐述了其在 肿瘤血管新生过程中表观遗传的调控作用。 [关键词]　肿瘤；血管生成；表观遗传学；甲基化；乙酰化 [中图分类号]　R730.53 [文献标志码]　A [文章编号]　1000-7431 (2012) 04-0301-07 Epigenetic changes of angiogenesis related factors in cancer LÜ Tian-jiao, FENG Wei-wei Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China [A BSTRACT]　Objective : During the process of pathogenesis, development and metastasis of cancer, angiogenesis, regulated by related genes, plays a crucial role. These invasive and metastatic cancer cells have undergone numerous genetic and epigenetic changes. Being different from genetic changes, most epigenetic changes are reversible. In order to develop new agents, the researchers are trying to use DNA methylation transferase inhibitors and histone deacetylase inhibitors against cancer and angiogenesis. To elucidate the role of epigenetic regulation in tumor angiogenesis, this review summarizes the epigenetic changes and significance of some genes related to angiogenesis. [KEY WORDS]　Neoplasms; Angiogenesis; Epigenetics; Methylation; Acethylation [ TUMOR , 2012, 32 (04) : 301-307] 表观遗传学是研究非DNA 序列改变的基因表达状态 皮生长因子受体2 （vascular endothelial growth factor A/ 的可遗传变化。表观遗传通过DNA 甲基化、组蛋白修饰、 v ascul