酿酒酵母基因表达的网络调控.ppt

酿酒酵母基因表达的网络调控 The yeast Saccharomyces cerevisiae,which at present is perhaps the best characterized model organism. Specificity and Stability in Topology of Protein NetworksSergei Maslov 1 and Kim Sneppen 23 MAY 2002 VOL 296 SCIENCE The interaction network used in this study consists of 4549 physical interactions between 3278 yeast proteins as measured in the most comprehensive two-hybrid screen of yeast proteins, whereas the genetic regulatory network is formed by 1289 directed positive or negative direct transcriptional regulations within a set of 682 proteins as listed in the Yeast Protein Database. Network of physical interactions between nuclear proteins. In this “null model” network, all proteins have exactly the same connectivity as in the original one, whereas the choice of their interaction partners is totally random. correlation profiles of protein interaction and regulatory networks in yeast correlations in connectivities of neighbors It is feasible that molecular networks in a living cell have organized themselves in an interaction pattern that is both robust and specific. Topologically, the specificity of different functional modules can be enhanced by limiting interactions between hubs and suppressing the average connectivity of their neighbors. Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network SCIENCE VOL 292 4 MAY 2001