病理学--肿瘤2.ppt

Intra-epithelial neoplasmThis covers the spectrum of changes short of invasive carcinoma Mild (CIN I) Moderate (CIN II) Severe (CIN III) III. (Biologic agents)  1. Tumor viruses 2. Bacteria: H. pylori 3. Parasite HIV HIV-1 HIV-2 III. (Biologic agents) 2. Bacteria: H. pylori VIII, H. pylori association  with gastric cancer.  There is a known stepwise progression from chronic superficial gastritis to intestinal type cancer. It is estimated that H. pylori infection increases the risk of gastric cancer 6 times. VIII, H. pylori association  with gastric cancer.  There have also been studies of gastric MALT lymphoma which is caused by B-cells stimulated by T-cells stimulated by H. pylori. Research has shown that 5 of 6 early lymphomas regressed after eradication of H. pylori. III. (Biologic agents) 3.Parasite: (Fluke(Blood flukes, Schistosome ) Section 14 Common tumors I. Epithelial Varieties II. Tumors of mesenchymal tissue ( connective tissue , soft tissue) Tumors of neuro-ectodermal orgin The difference between carcinoma and sarcoma I. Epithelial Varieties 1.benign: a. papilloma b. adenoma 2. malignancy papiloma squamous cell carcinoma location Covered by squamous cell Covered by squamous cell and squamous metaplasia Naked-eye appearen-ce Papillae or long finger-like process Papillae, dome-shaped, Irregularly nodular or cauliflower-like Growth model Exophytic growth Invasive growth Microsco-pic feature 1 atypia of architecture 2 disordered squamous epithelium 1the basic feature of carcinoma 2forming cell nests and keratin I. Epithelial Varieties 1. Benign: papilloma adenoma .The concept of differentiation is demonstrated by this small adenomatous polyp of the colon. Note the difference in staining quality between the